Document Detail

Cardiac ectopy in chronic autonomic failure.
MedLine Citation:
PMID:  20012145     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Chronic autonomic failure (CAF), as in Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic failure (PAF), typically entails baroreflex failure, neurogenic orthostatic hypotension (NOH), and supine hypertension. The combination might predispose to cardiac ectopy, which in turn might predispose to syncope and falls during manipulations decreasing venous return to the heart. This study assessed whether CAF is associated with an increased prevalence of cardiac ectopy. METHODS: Recordings lasting > or = 15 min of the electrocardiogram, beat-to-beat heart rate, and continuous blood pressure were reviewed from a total of 97 CAF patients (34 PD + NOH, 48 MSA, 15 PAF) and 82 control subjects (41 PD without NOH, 33 non-parkinsonian patients, 8 healthy volunteers). Cardiac ectopy was considered present if there were at least two premature beats or an arrhythmia. RESULTS: Atrial ectopy was found in 74% of patients with PD + NOH, 68% with MSA, and 63% with PAF, prevalences 2-3 times those in PD without NOH (28%, p < 0.0001) or other controls (24%, p < 0.0001). Atrial ectopy was related to subject age (p < 0.0001), supine systolic pressure (p < 0.0001), and the orthostatic fall in systolic pressure (p = 0.0007) and inversely with baroreflex-cardiovagal gain (p = 0.005) and the orthostatic increment in plasma norepinephrine (p = 0.0004). In two PD + NOH patients, atrial ectopy was associated with documented sustained hypotension after the Valsalva maneuver; and in an MSA patient, acute atrial flutter/fibrillation was associated with sudden loss of consciousness. INTERPRETATION: CAF patients have a relatively high frequency of atrial ectopy, which might interact with baroreflex failure to increase morbidity from orthostatic hypotension.
David S Goldstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2009-12-11
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  20     ISSN:  1619-1560     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive MSC-1620, Building 10 Room 5N220, Bethesda, MD 20892-1620, USA.
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MeSH Terms
Atrial Premature Complexes / epidemiology*,  physiopathology*
Baroreflex / physiology
Case-Control Studies
Chronic Disease
Heart Rate / physiology
Hypotension, Orthostatic / complications,  physiopathology
Middle Aged
Multiple System Atrophy / complications,  physiopathology
Parkinson Disease / complications,  physiopathology
Pure Autonomic Failure / complications*,  physiopathology*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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