| Cardiac dysrhythmias in severe verapamil overdose: characterization with a canine model. | |
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MedLine Citation:
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PMID: 8886664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Verapamil overdose, because of its frequency and severity, represents a significant problem for the emergency physician. With recent search recommending specific therapies for verapamil toxicity, aids to rapid diagnosis hold promise for decreasing morbidity and mortality from overdose of all calcium channel blockers. At this time, diagnosis of verapamil toxicity depends primarily on patient history and identification of cardiac dysrhythmias. This study attempts to improve the diagnostic armamentarium available for verapamil poisoning by analysing cardiac conduction problems seen in a canine model of verapamil toxicity, with the goal of identifying clinically useful dysrhythmia patterns. In 43 verapamil-toxic animals, junctional rhythm without organized atrial activity was the most frequently identified rhythm (55.6%). The next most commonly seen rhythms were tertiary atrioventricular (AV) block (16.3%) and idioventricular rhythm (11.6%); other animals manifested low grade AV block. Of interest, prominent U waves were noted in 25.6% of animals. While these results are subject to the limitations inherent in the use of an animal model, the data generated provide potentially useful patterns of dysrhythmia which may be encountered in humans with verapamil toxicity. |
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Authors:
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S H Thomas; C K Stone; S I Koury |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of emergency medicine : official journal of the European Society for Emergency Medicine Volume: 3 ISSN: 0969-9546 ISO Abbreviation: Eur J Emerg Med Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1997-01-27 Completed Date: 1997-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442482 Medline TA: Eur J Emerg Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 9-13 Citation Subset: IM |
Affiliation:
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Division of Emergency Medicine, Harvard Medical School, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channel Blockers / poisoning* Disease Models, Animal* Dogs Electrocardiography Heart Block / chemically induced*, classification, diagnosis Overdose / complications Verapamil / poisoning* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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