Document Detail

Cardiac dysrhythmias and heart rate changes at induction of anaesthesia: a comparison of two intravenous anticholinergics.
MedLine Citation:
PMID:  6375235     Owner:  NLM     Status:  MEDLINE    
Glycopyrrolate, 0.2 mg, or atropine, 0.6 mg, was administered intravenously together with methohexitone for the induction of anaesthesia in unpremedicated patients. The use of atropine, compared with glycopyrrolate, was associated with a greater rise in heart rate, a greater number of patients whose heart rates doubled, and a higher incidence of dysrhythmias. Glycopyrrolate is recommended for use as an intravenous anticholinergic agent, particularly in patients with cardiovascular impairment.
J Greenan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  28     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-10     Completed Date:  1984-07-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  182-4     Citation Subset:  IM    
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MeSH Terms
Anesthesia, Intravenous*
Arrhythmias, Cardiac / chemically induced*
Atropine / administration & dosage,  adverse effects
Clinical Trials as Topic
Double-Blind Method
Glycopyrrolate / administration & dosage,  adverse effects
Heart Rate / drug effects*
Injections, Intravenous
Methohexital / administration & dosage,  adverse effects
Middle Aged
Parasympatholytics / administration & dosage,  adverse effects*
Random Allocation
Reg. No./Substance:
0/Parasympatholytics; 18652-93-2/Methohexital; 51-55-8/Atropine; 596-51-0/Glycopyrrolate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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