Document Detail


Cardiac dysrhythmias and heart rate changes at induction of anaesthesia: a comparison of two intravenous anticholinergics.
MedLine Citation:
PMID:  6375235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycopyrrolate, 0.2 mg, or atropine, 0.6 mg, was administered intravenously together with methohexitone for the induction of anaesthesia in unpremedicated patients. The use of atropine, compared with glycopyrrolate, was associated with a greater rise in heart rate, a greater number of patients whose heart rates doubled, and a higher incidence of dysrhythmias. Glycopyrrolate is recommended for use as an intravenous anticholinergic agent, particularly in patients with cardiovascular impairment.
Authors:
J Greenan
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  28     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-10     Completed Date:  1984-07-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  182-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Anesthesia, Intravenous*
Arrhythmias, Cardiac / chemically induced*
Atropine / administration & dosage,  adverse effects
Clinical Trials as Topic
Double-Blind Method
Electrocardiography
Female
Glycopyrrolate / administration & dosage,  adverse effects
Heart Rate / drug effects*
Humans
Injections, Intravenous
Male
Methohexital / administration & dosage,  adverse effects
Middle Aged
Parasympatholytics / administration & dosage,  adverse effects*
Random Allocation
Chemical
Reg. No./Substance:
0/Parasympatholytics; 18652-93-2/Methohexital; 51-55-8/Atropine; 596-51-0/Glycopyrrolate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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