Document Detail

Cardiac dysfunction in rats prone to audiogenic epileptic seizures.
MedLine Citation:
PMID:  23340275     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Cardiac dysfunction is one of the possible causes of sudden unexpected death in epilepsy (SUDEP). Therefore, the objective of this study was to evaluate cardiac and electrocardiographic parameters in rats with audiogenic epileptic seizures (WAR--Wistar audiogenic rats).
METHODS: In vivo arterial pressure, heart rate (HR), autonomic tone and electrocardiography (ECG) were measured in awake animals in order to examine cardiac function and rhythm. Ex vivo, the Langendorff technique was used to analyze the cardiac function and the severity of reperfusion arrhythmias. In vitro, confocal microscopy was used to evaluate calcium transient parameters of isolated ventricular cardiomyocytes.
RESULTS: In vivo autonomic tone evaluation revealed enhanced sympathetic activity, changes in cardiac function with increased systolic arterial pressure and higher basal HR in WAR. In addition, ECG analysis demonstrated electrical alterations with prolongation of the QT interval and QRS complex in these animals. Ex vivo, we observed a decrease in systolic tone and HR and an increase in the duration of ischemia/reperfusion arrhythmias in WAR. Moreover, intracellular Ca2+ handling analysis revealed an increase in the peak of calcium and calcium transient decay in audiogenic rats. Treatment with atenolol (β1-adrenergic antagonist) normalized the systolic tone, reduced cardiac hypertrophy and the associated increase in the susceptibility to reperfusion arrhythmias observed in WAR.
CONCLUSION: We present evidence that chronic disturbances in sympathetic tone in WAR cause increases the risk to life-threatening arrhythmias. Our results support a relationship between seizures, cardiac dysfunction and cardiac arrhythmias, which may contribute to the occurrence of SUDEP.
Denis D Damasceno; Silvia Q Savergnini; Enéas R M Gomes; Silvia Guatimosim; Anderson J Ferreira; Maria C Doretto; Alvair P Almeida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-20
Journal Detail:
Title:  Seizure     Volume:  22     ISSN:  1532-2688     ISO Abbreviation:  Seizure     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-10     Completed Date:  2014-01-20     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Acoustic Stimulation / adverse effects*
Arrhythmias, Cardiac / complications,  physiopathology*
Blood Pressure / physiology
Electrocardiography / methods
Epilepsy, Reflex / complications,  physiopathology*
Heart Rate / physiology
Rats, Wistar
Seizures / complications,  physiopathology*

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