| Cardiac dysfunction in patients seropositive for the human immunodeficiency virus. | |
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MedLine Citation:
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PMID: 1771874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To confirm the presence of cardiac dysfunction in a group of patients seropositive for the human immunodeficiency virus with either dyspnea on exertion or a reduced anaerobic threshold, 9 patients with no history of opportunistic infection underwent exercise right-sided heart catheterization. When compared with 13 control patients previously exercised in the same manner, the patients showed elevated exercise pulmonary capillary wedge pressure (14.6 +/- 3.3 mm of mercury versus 9.9 +/- 3.3 mm of mercury; P less than .005) and right atrial pressure (10.1 +/- 2.1 mm of mercury versus 4.7 +/- 3.2 mm of mercury; P less than .001) at a similar exercise oxygen consumption and cardiac index. Of the 9 patients, 8 had at least 1 catheterization value outside the 95% confidence limits for the control group and 4 patients had multiple abnormalities. Values for blood CD4 lymphocytes were 0.2 x 10(9) per liter or more for 7 of the 9. One patient underwent endomyocardial biopsy with findings consistent with a cardiomyopathy. We conclude that cardiac disease may occur at any immunologic stage of human immunodeficiency virus infection. These observations suggest an effect of this disease on the heart. |
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Authors:
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J E Johnson; D M Slife; G T Anders; S R Bailey; H M Blanton; C K McAllister; R D Latham |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Western journal of medicine Volume: 155 ISSN: 0093-0415 ISO Abbreviation: West. J. Med. Publication Date: 1991 Oct |
Date Detail:
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Created Date: 1992-02-26 Completed Date: 1992-02-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0410504 Medline TA: West J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 373-9 Citation Subset: AIM; IM; X |
Affiliation:
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Pulmonary Disease/Critical Care Service, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Electrocardiography Exercise Test HIV Seropositivity / complications, pathology, physiopathology* Heart / physiopathology* Heart Catheterization Heart Diseases / complications Hemodynamics Humans Male Myocardium / pathology |
| Comments/Corrections | |
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