Document Detail

Cardiac dysfunction after burns.
MedLine Citation:
PMID:  18378089     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Using transoesophageal echocardiography (TEE) we investigated the occurrence, and the association of possible abnormalities of motion of the regional wall of the heart (WMA) or diastolic dysfunction with raised troponin concentrations, or both during fluid resuscitation in patients with severe burns. PATIENTS AND METHODS: Ten consecutive adults (aged 36-89 years, two women) with burns exceeding 20% total burned body surface area who needed mechanical ventilation were studied. Their mean Baux index was 92.7, and they were resuscitated according to the Parkland formula. Thirty series of TEE examinations and simultaneous laboratory tests for myocyte damage were done 12, 24, and 36h after the burn. RESULTS: Half (n=5) the patients had varying grades of leakage of the marker that correlated with changeable WMA at 12, 24 and 36h after the burn (p< or =0.001, 0.044 and 0.02, respectively). No patient had WMA and normal concentrations of biomarkers or vice versa. The mitral deceleration time was short, but left ventricular filling velocity increased together with stroke volume. CONCLUSION: Acute myocardial damage recorded by both echocardiography and leakage of troponin was common, and there was a close correlation between them. This is true also when global systolic function is not deteriorated. The mitral flow Doppler pattern suggested restrictive left ventricular diastolic function.
Z Bak; F Sjöberg; O Eriksson; I Steinvall; B Janerot-Sjoberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-02
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  34     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  603-9     Citation Subset:  IM    
Department of Anesthesia and Intensive Care, Linköping University Hospital, Sweden.
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MeSH Terms
Biological Markers / blood
Burns / complications*,  physiopathology,  therapy
Echocardiography, Transesophageal
Fluid Therapy
Heart Injuries / etiology*,  physiopathology,  ultrasonography
Intermittent Positive-Pressure Ventilation
Middle Aged
Prospective Studies
Trauma Severity Indices
Troponin / blood
Ventricular Dysfunction, Left / etiology,  physiopathology,  ultrasonography
Reg. No./Substance:
0/Biological Markers; 0/Troponin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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