Document Detail

Cardiac diastolic abnormalities and atrial natriuretic factor in essential hypertension.
MedLine Citation:
PMID:  8375414     Owner:  NLM     Status:  MEDLINE    
Cardiac function and plasma levels of atrial natriuretic factor (ANF) were studied in a group of 38 patients with untreated essential hypertension and in a group of 31 well matched normotensive controls. ANF was slightly but significantly higher in hypertensives and was directly correlated with mean arterial pressure and inversely with plasma renin activity (PRA). Hypertensives showed normal systolic function and higher cardiac mass compared to controls. ANF was inversely correlated to echocardiographic indexes of left ventricular performance in the former group. At Doppler echocardiographic evaluation, hypertensives showed an impairment in diastolic function which was correlated to the increase in ANF levels. Stepwise multiple regression analysis performed with ANF as the dependent variable and several biohumoral and echocardiographic parameters as the independent variables showed that only cardiac diastolic function and PRA significantly affect ANF levels in hypertensives. In conclusion, an impairment in cardiac diastolic function may be responsible together with other factors for the increased ANF levels encountered in essential hypertension.
R Pontremoli; G P Bezante; C Robaudo; F Massarino; A Sofia; G Bertero; G Gnecco; C Pastorini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  14     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-15     Completed Date:  1993-10-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  910-4     Citation Subset:  IM    
Department of Internal Medicine, University of Genoa, Italy.
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MeSH Terms
Atrial Natriuretic Factor / blood*
Blood Pressure
Diastole / physiology*
Echocardiography, Doppler
Hypertension / blood,  physiopathology*
Renin / blood
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor; EC

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