Document Detail

Cardiac depression and cellular injury in hemorrhagic shock and reinfusion: role of free radicals.
MedLine Citation:
PMID:  9406175     Owner:  NLM     Status:  MEDLINE    
We investigated the effect of hemorrhagic shock and reinfusion on the cardiac function and contractility, plasma CK and CK-MB activity and lactate concentration, oxyradical-producing activity of polymorphonuclear leukocytes (PMNL-CL), cardiac chemiluminescence (LV-CL), antioxidant enzyme activity [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX)] and malondialdehyde (MDA) concentration in anesthetized dogs to determine the role of oxyradicals in cardiac depression and cellular injury in hemorrhagic shock and reinfusion. The dogs were assigned into three groups: I (sham), 4 h duration; II (S + R), 2 h of shock followed by reinfusion for 2 h; III (SOD + S + R), as II but pretreated with PEG-SOD. Hemorrhagic shock was produced by withdrawal of blood to maintain the mean arterial pressure at 50 +/- 5 mm Hg. Cardiac function and contractility were depressed during hemorrhagic shock. Plasma CK, CK-MB and lactate increased during shock. Following reinfusion after 2 h of shock hemodynamic parameters and plasma lactate tended to return towards control values. Plasma CK and CK-MB, PMNL-CL and cardiac MDA, total-, Mn- and CuZn-SOD activity increased while LV-CL decreased. In spite of the increase in the antioxidant reserve, there was oxidative damage. Pretreatment with SOD attenuated the deleterious effects of shock and reinfusion on the cardiovascular function, plasma CK, and CK-MB, PMNL-CL, cardiac MDA, SOD, and LV-CL. Protection was incomplete for cardiovascular function and plasma CK and CK-MB. These results suggest that oxyradicals may partly be involved in the deterioration of cardiovascular function and cellular injury during hemorrhagic shock and reinfusion.
R Kapoor; J Kalra; K Prasad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  176     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-23     Completed Date:  1998-01-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  291-301     Citation Subset:  IM    
Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Catalase / metabolism
Chemiluminescent Measurements
Creatine Kinase / blood
Free Radicals / pharmacology
Glutathione Peroxidase / metabolism
Lactic Acid / blood*
Malondialdehyde / metabolism
Oxidoreductases / metabolism*
Pulmonary Artery / physiology
Pulmonary Wedge Pressure / physiology
Shock, Hemorrhagic / blood,  physiopathology*
Stroke Volume / physiology
Superoxide Dismutase / metabolism
Ventricular Function
Reg. No./Substance:
0/Free Radicals; 50-21-5/Lactic Acid; 542-78-9/Malondialdehyde; EC 1.-/Oxidoreductases; EC; EC Peroxidase; EC Dismutase; EC Kinase

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