| Cardiac depression and cellular injury in hemorrhagic shock and reinfusion: role of free radicals. | |
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MedLine Citation:
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PMID: 9406175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effect of hemorrhagic shock and reinfusion on the cardiac function and contractility, plasma CK and CK-MB activity and lactate concentration, oxyradical-producing activity of polymorphonuclear leukocytes (PMNL-CL), cardiac chemiluminescence (LV-CL), antioxidant enzyme activity [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-PX)] and malondialdehyde (MDA) concentration in anesthetized dogs to determine the role of oxyradicals in cardiac depression and cellular injury in hemorrhagic shock and reinfusion. The dogs were assigned into three groups: I (sham), 4 h duration; II (S + R), 2 h of shock followed by reinfusion for 2 h; III (SOD + S + R), as II but pretreated with PEG-SOD. Hemorrhagic shock was produced by withdrawal of blood to maintain the mean arterial pressure at 50 +/- 5 mm Hg. Cardiac function and contractility were depressed during hemorrhagic shock. Plasma CK, CK-MB and lactate increased during shock. Following reinfusion after 2 h of shock hemodynamic parameters and plasma lactate tended to return towards control values. Plasma CK and CK-MB, PMNL-CL and cardiac MDA, total-, Mn- and CuZn-SOD activity increased while LV-CL decreased. In spite of the increase in the antioxidant reserve, there was oxidative damage. Pretreatment with SOD attenuated the deleterious effects of shock and reinfusion on the cardiovascular function, plasma CK, and CK-MB, PMNL-CL, cardiac MDA, SOD, and LV-CL. Protection was incomplete for cardiovascular function and plasma CK and CK-MB. These results suggest that oxyradicals may partly be involved in the deterioration of cardiovascular function and cellular injury during hemorrhagic shock and reinfusion. |
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Authors:
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R Kapoor; J Kalra; K Prasad |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 176 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-01-23 Completed Date: 1998-01-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 291-301 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catalase / metabolism Chemiluminescent Measurements Creatine Kinase / blood Dogs Female Free Radicals / pharmacology Glutathione Peroxidase / metabolism Hemodynamics Lactic Acid / blood* Male Malondialdehyde / metabolism Neutrophils Oxidoreductases / metabolism* Pulmonary Artery / physiology Pulmonary Wedge Pressure / physiology Shock, Hemorrhagic / blood, physiopathology* Stroke Volume / physiology Superoxide Dismutase / metabolism Ventricular Function |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 50-21-5/Lactic Acid; 542-78-9/Malondialdehyde; EC 1.-/Oxidoreductases; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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