Document Detail


Cardiac depressant factors in renal disease.
MedLine Citation:
PMID:  8387405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic (CRF) and acute renal failure (ARF) are accompanied by cardiac dysfunction, particularly if ARF is complicated by sepsis. Intermyocardiocytic fibrosis is described in CRF, but there is also evidence for functional cardiomyopathy. Acetate ion (present in the dialysate) and secondary hyperparathyroidism do not appear to be clinically relevant myocardial depressant factors in uremia. The role of carnitine deficiency is not clarified, because most of the data are evaluated in poorly controlled study trials. Multiple effects of serum fractions and ultrafiltrates obtained from CRF and ARF patients during dialysis suggest the existence of myocardial depressant factor(s). Beneficial effects of continuous hemofiltration in multiorgan failure give evidence for the pathogenetic role of this substance(s). One group of experiments suggests a molecular weight between 500 and 5,000 d; other experiments suggest activity at > 10,000 d. It is currently believed that myocardial depressant substance is a water-soluble molecule weighing 10,000-30,000 d. The data confirm the existence of "specific cardiomyopathy" caused by a functional defect related to filterable toxins. There are different myocardial depressant factors in CRF, ARF, and sepsis.
Authors:
W H Hörl; W Riegel
Related Documents :
11276095 - Advances in human cardiac 31p-mr spectroscopy: sloop and clinical applications.
9715325 - Embolic stroke in a child with idiopathic dilated cardiomyopathy.
6543375 - Adverse effect of nifedipine on left ventricular obstruction detected by pulsed doppler...
139105 - Echocardiography in the differential diagnosis of the large heart.
11024385 - Left ventricular regional wall motion, ejection fraction, and geometry after partial le...
10750695 - N-3 polyunsaturated fatty acids and the cardiovascular system.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Circulation     Volume:  87     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-10     Completed Date:  1993-06-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  IV77-82     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, University of Saarland, Homburg, FRG.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetates / metabolism
Animals
Cardiomyopathies / etiology
Heart / physiopathology*
Humans
Ions
Kidney Diseases / physiopathology*
Kidney Failure, Chronic / complications
Multiple Organ Failure / etiology
Myocardium / metabolism
Parathyroid Hormone / physiology
Receptors, Adrenergic, beta / physiology
Renal Dialysis
Uremia / blood,  therapy
Chemical
Reg. No./Substance:
0/Acetates; 0/Ions; 0/Parathyroid Hormone; 0/Receptors, Adrenergic, beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cellular aspects of cardiac failure.
Next Document:  Stimulation of rat Schwann cell proliferation by estradiol: synergism between the estrogen and cAMP.