Document Detail

Cardiac defects in chromosomally normal fetuses with increased nuchal translucency at 10-14 weeks of gestation.
MedLine Citation:
PMID:  12820838     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the prevalence, distribution and spectrum of cardiac defects in chromosomally normal fetuses with increased nuchal translucency thickness. PATIENTS AND METHODS: During a 4-year period, targeted fetal echocardiography was used in 353 chromosomally normal fetuses with increased nuchal translucency thickness at 10-14 weeks' gestation. The cardiac scan was performed at 18-22 weeks. In the last 138 cases enrolled, an additional scan at 12-16 weeks was carried out. The follow-up included the findings at necropsy or in the pediatric examination. A complete follow-up was achieved in 97%. RESULTS: Cardiac defects were present in 32 (9.1%) cases, increasing from 5.3% in those with a nuchal translucency thickness of > or = 95th centile (3.9 mm) to 24% when thickness > or = 6 mm (p < 0.001). In 31 cases (97%), the cardiac defect was diagnosed antenatally; in 24 cases (77%) this diagnosis was confirmed later. In the remaining seven cases, the autopsy examination was not available. A wide range of cardiac defects was observed, with the most common being atrioventricular septal defect and tricuspid atresia. CONCLUSIONS: Euploid fetuses with increased nuchal translucency thickness have a significantly increased risk of cardiac defects. This is a marker of different types of heart anomalies and constitutes an additional indication for targeted fetal echocardiography. Most of the cardiac defects can be detected by fetal echocardiography.
A Galindo; C Comas; J M Martínez; F Gutiérrez-Larraya; J M Carrera; B Puerto; A Borrell; C Mortera; P de la Fuente
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  13     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-06-24     Completed Date:  2003-07-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-70     Citation Subset:  IM    
Ultrasound and Fetal Physiopathology Unit, Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, Madrid, Spain.
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MeSH Terms
Cardiovascular Abnormalities / epidemiology*,  etiology,  genetics,  ultrasonography*
Chromosomes, Human
Heart Septal Defects / epidemiology,  ultrasonography
Neck / embryology,  ultrasonography*
Pregnancy Trimester, First
Spain / epidemiology
Tricuspid Atresia / epidemiology,  ultrasonography
Ultrasonography, Prenatal*

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