| Cardiac defects in chromosomally normal fetuses with increased nuchal translucency at 10-14 weeks of gestation. | |
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MedLine Citation:
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PMID: 12820838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine the prevalence, distribution and spectrum of cardiac defects in chromosomally normal fetuses with increased nuchal translucency thickness. PATIENTS AND METHODS: During a 4-year period, targeted fetal echocardiography was used in 353 chromosomally normal fetuses with increased nuchal translucency thickness at 10-14 weeks' gestation. The cardiac scan was performed at 18-22 weeks. In the last 138 cases enrolled, an additional scan at 12-16 weeks was carried out. The follow-up included the findings at necropsy or in the pediatric examination. A complete follow-up was achieved in 97%. RESULTS: Cardiac defects were present in 32 (9.1%) cases, increasing from 5.3% in those with a nuchal translucency thickness of > or = 95th centile (3.9 mm) to 24% when thickness > or = 6 mm (p < 0.001). In 31 cases (97%), the cardiac defect was diagnosed antenatally; in 24 cases (77%) this diagnosis was confirmed later. In the remaining seven cases, the autopsy examination was not available. A wide range of cardiac defects was observed, with the most common being atrioventricular septal defect and tricuspid atresia. CONCLUSIONS: Euploid fetuses with increased nuchal translucency thickness have a significantly increased risk of cardiac defects. This is a marker of different types of heart anomalies and constitutes an additional indication for targeted fetal echocardiography. Most of the cardiac defects can be detected by fetal echocardiography. |
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Authors:
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A Galindo; C Comas; J M Martínez; F Gutiérrez-Larraya; J M Carrera; B Puerto; A Borrell; C Mortera; P de la Fuente |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 13 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-06-24 Completed Date: 2003-07-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 163-70 Citation Subset: IM |
Affiliation:
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Ultrasound and Fetal Physiopathology Unit, Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cardiovascular Abnormalities / epidemiology*, etiology, genetics, ultrasonography* Chromosomes, Human Echocardiography Female Heart Septal Defects / epidemiology, ultrasonography Humans Neck / embryology, ultrasonography* Pregnancy Pregnancy Trimester, First Prevalence Spain / epidemiology Tricuspid Atresia / epidemiology, ultrasonography Ultrasonography, Prenatal* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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