| Cardiac death and heart failure following primary angioplasty in extensive myocardial infarction: incremental prognostic value of clinical, functional and angiographic data. | |
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MedLine Citation:
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PMID: 15706996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The incidence of late severe heart failure after primary angioplasty is not clear and few data are available about the clinical prognostic predictors of this event. The aims of our study were a) to evaluate the incidence of cardiac death and heart failure after an extensive acute myocardial infarction treated with primary angioplasty, and b) to identify, among clinical, ECG, functional, and angiographic variables, the outcome predictors and their incremental prognostic value. METHODS: Two hundred and thirty-three patients with ST-segment elevation in > or = 4 leads, without cardiogenic shock, underwent primary angioplasty within 12 hours of symptom onset and were prospectively followed up for a median of 21 months for the combined endpoint of cardiac death and heart failure. The effects of clinical, ECG, functional, and angiographic data on the combined endpoint were evaluated using Cox's analysis. Separate models were developed including all variables of a given model plus significant variables of previous models to reproduce the usual clinical information flow. RESULTS: Twelve (5%) deaths and 23 (10%) heart failures occurred. Diabetes (hazard ratio [HR] 6.46, 95% confidence interval [CI] 1.99-20.98) and peak creatine kinase-MB (HR 1.002, 95% CI 1.001-1.004 per unit increment), wall motion score index (HR 1.46, 95% CI 0.35-6.15 per 0.1 unit increment), and TIMI flow grade < 3 after angioplasty (HR 5.35, 95% CI 2.04-14.02) were the only significant and independent prognostic indicators. ECG information did not improve the model, whilst functional and angiographic data provided incremental prognostic value over clinical information. CONCLUSIONS: At mid-term follow-up, extensive acute myocardial infarction patients undergoing primary angioplasty have a moderate heart failure event rate. The integrated evaluation of data routinely available from diagnostic work-up allows accurate prediction of the outcome; functional and angiographic data provide incremental prognostic information over clinical and ECG variables. |
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Authors:
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Elena Corrada; Riccardo Bigi; Paola Colombo; Irene Bossi; Anna Maria De Biase; Antonio Mafrici; Oberdan Parodi; Silvio Klugmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Italian heart journal : official journal of the Italian Federation of Cardiology Volume: 5 ISSN: 1129-471X ISO Abbreviation: Ital Heart J Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2005-02-14 Completed Date: 2005-05-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100909716 Medline TA: Ital Heart J Country: Italy |
Other Details:
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Languages: eng Pagination: 912-8 Citation Subset: IM |
Affiliation:
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Cardiothoracic and Vascular Department A. De Gasperis, National Research Council, Niguarda Ca' Granda Hospital, Milan, Italy. elena.corrada@fastwebnet.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary* Disease-Free Survival Female Follow-Up Studies Heart Failure / etiology*, mortality* Humans Male Middle Aged Myocardial Infarction / complications, diagnosis*, therapy* Prognosis Prospective Studies Risk Factors Severity of Illness Index Time Factors |
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