Document Detail

Cardiac damage from chronic use of chloroquine: a case report and review of the literature.
MedLine Citation:
PMID:  12163948     Owner:  NLM     Status:  MEDLINE    
Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology.
Ricardo Alkmim Teixeira; Martino Martinelli Filho; Luiz Alberto Benvenuti; Roberto Costa; Anísio A Pedrosa; Silvana A D Nishióka
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Arquivos brasileiros de cardiologia     Volume:  79     ISSN:  0066-782X     ISO Abbreviation:  Arq. Bras. Cardiol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-06     Completed Date:  2002-10-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0421031     Medline TA:  Arq Bras Cardiol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
Heart Institute, Medical School, University of São Paulo, São Paulo, SP, Brazil.
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MeSH Terms
Antirheumatic Agents / adverse effects*
Arthritis, Rheumatoid / drug therapy
Chloroquine / adverse effects*
Heart Diseases / chemically induced*,  pathology
Middle Aged
Time Factors
Reg. No./Substance:
0/Antirheumatic Agents; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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