Document Detail


Cardiac damage caused by direct application of defibrillator shocks to isolated Langendorff-perfused rabbit heart.
MedLine Citation:
PMID:  7415935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to establish the damaging dose of defibrillator pulses. The damage caused to isolated perfused rabbit hearts by synchronized defibrillator shocks with a stored energy from 15 up to 70 joules is reported. The damage was characterized by the duration and severity of post-shock arrhythmias, changes in the elastic properties of the left ventricle, the first derivative of left ventricular pressure, morphological changes of the heart muscle, elevation of creating kinase, potassium washout, and a change in mean coronary flow rate. Varying the electrode area showed that densities of applied current and energy are major factors in damaging the heart. At current and energy densities of 0.5 amp./cm.2 and 0.6 J./cm.2, respectively, potassium washout and mild arrhythmias are seen, as is complete arrest of the ventricles at 1.2 amp./cm.2 and 1.5 J./cm.2 pulses. After 1.8 amp./cm.2, irreversible cell damage occurs, as demonstrated by CK release, and also cardiac function is reduced, measured by increased diastolic stiffness and decreased contractility. Current and energy densities exceeding 2.5 amp./cm.2 and 4.2 J./cm.2, respectively, cause changes in cardiac function incompatible with life. Accumulation of damage was observed with a series of 1.2 amp./cm.2 shocks.
Authors:
G Koning; A H Veefkind; H Schneider
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  100     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1980-11-25     Completed Date:  1980-11-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-82     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arrhythmias, Cardiac / etiology
Blood Pressure
Blood Volume
Creatine Kinase / metabolism
Diastole
Electric Countershock*
Heart Injuries / etiology*
Heart Ventricles / pathology,  ultrastructure
Perfusion*
Rabbits
Systole
Chemical
Reg. No./Substance:
EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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