| Cardiac correlates of exercise induced pulmonary hypertension in patients with chronic heart failure due to left ventricular systolic dysfunction. | |
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MedLine Citation:
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PMID: 18177381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with chronic heart failure (CHF) due to left ventricular systolic dysfunction (LVSD) may develop pulmonary hypertension at rest and during exercise. The cardiac correlates of pulmonary hypertension have been ascertained in the resting state, but seldom during exercise in these patients. AIMS: We sought to determine the cardiac correlates of exercise induced pulmonary hypertension in patients with LVSD by monitoring the estimated pulmonary artery systolic pressure (PASP) by continuous Doppler echocardiography during semirecumbent bicycle exercise. METHODS: Eighty-five patients (mean age 57 +/- 13 years, 75% male) with CHF due to LVSD (LV ejection fraction [EF] <45%, mean LVEF 26 +/- 8%) were studied. RESULTS: Mitral effective regurgitant orifice area and E-wave were independent predictors of resting PASP. Resting PASP and exercise induced changes in PASP were unrelated (r =-0.08, P = 0.45). Decrease in LV end-systolic volume, increase in left atrial (LA) area, resting LV asynchrony, and decreased tricuspid annular plane systolic excursion (TAPSE) were independent predictors of exercise PASP. CONCLUSIONS: Resting LV asynchrony, impaired LV contractile reserve, and increase in LA dilatation correlate with the severity of exercise induced pulmonary hypertension in patients with CHF due to LVSD, while right ventricular systolic dysfunction is inversely related to the severity of exercise induced pulmonary hypertension. |
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Authors:
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Sylvestre Maréchaux; Claire Pinçon; Thierry Le Tourneau; Pascal de Groote; Clémence Huerre; Philippe Asseman; Eric Van Belle; Rémi Nevière; Christophe Bauters; Ghislaine Deklunder; Thierry H Lejemtel; Pierre V Ennezat |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-01-03 |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 25 ISSN: 0742-2822 ISO Abbreviation: Echocardiography Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-27 Completed Date: 2008-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 386-93 Citation Subset: IM |
Affiliation:
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Physiology Department, Centre Hospitalier Régional et Universitaire de Lille, Lille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chronic Disease Disease Progression Echocardiography, Doppler / methods Exercise Test / adverse effects* Female Heart Failure / complications*, physiopathology, ultrasonography Humans Hypertension, Pulmonary / etiology*, physiopathology, ultrasonography Male Middle Aged Prognosis Risk Factors Severity of Illness Index Stroke Volume / physiology Systole Ventricular Dysfunction, Left / complications*, physiopathology, ultrasonography Ventricular Pressure / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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