| Cardiac contraction and intramyocardial venous pressure generation in the anaesthetized dog. | |
| | |
MedLine Citation:
|
PMID: 7869249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Two hypotheses relating to the influence of contraction of the heart on coronary venous pressure (Pv) were tested. The first assumes a direct transmission of left ventricular pressure (PLV). According to the alternative hypothesis the Pv is caused by cyclical changes in the elastance of the surrounding tissue. 2. A small epicardial vein was cannulated retrogradely in eight open-chest dogs deeply anaesthetized with fentanyl. The duration of diastoles was varied after induction of a heart block with formaldehyde. Coronary arterial inflow and perfusion pressure were controlled by a perfusion system connected to the left main coronary artery by a Gregg cannula. Stopped-flow Pv was studied with intrinsic coronary tone (IT) and after maximal dilatation with adenosine. 3. The Pv pulse in the first contraction after a long diastole was not significantly correlated to the PLV pulse, with a slope of 0.5, in any dog, either with IT or during adenosine treatment. Comparing the first contraction after the long diastole with the last beat before, systolic Pv pulse decreased significantly in seven out of eight dogs, but systolic PLV pulse increased in five dogs and was unaltered in three dogs in both conditions. In contrast, end-diastolic Pv was significantly correlated to the systolic Pv in each individual animal under either condition. 4. The results indicate that pressure generation in the small coronary veins can be explained on the basis of the time-varying elastance hypothesis and that a direct transmission of PLV to Pv is absent. |
| | |
Authors:
|
I Vergroesen; Y Han; M Goto; J A Spaan |
Related Documents
:
|
15162979 - Role of prehypertension in the development of coronary atherosclerosis in japan. 12219879 - Inflection point of ascending aortic waveform is a powerful predictor of restenosis aft... 9293969 - Are the inotropic and antiarrhythmic effects of bradykinin due to increases in coronary... 11458619 - The pressure waveform of coronary sinus in human hearts. 2376989 - System analysis of the dynamic response of the coronary circulation to a sudden change ... 6666229 - Hemodynamic effects of isosorbide-5-mononitrate in acute and chronic treatment of coron... 20690889 - Combinations of inhibitors of the renin-angiotensin system with calcium channel blocker... 7721409 - Natriuretic response to neutral endopeptidase inhibition is blunted by enalapril in hea... 9217589 - Vascular abnormalities associated with long-term cigarette smoking identified by arteri... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of physiology Volume: 480 ( Pt 2) ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1994 Oct |
Date Detail:
|
Created Date: 1995-03-24 Completed Date: 1995-03-24 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 343-53 Citation Subset: IM |
Affiliation:
|
Department of Medical Physics and Medical Informatics, Faculty of Medicine, University of Amsterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine
/
pharmacology Anesthesia Animals Coronary Circulation / physiology Coronary Vessels / physiology Diastole / physiology Dogs Heart / physiology* Models, Cardiovascular Myocardial Contraction / physiology* Perfusion Vasodilation / drug effects Venous Pressure / physiology* Ventricular Function, Left / physiology |
| Chemical | |
Reg. No./Substance:
|
58-61-7/Adenosine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electrophysiological studies of the interaction between ventricular myocardium and coronary artery i...
Next Document: Dynamic asymmetries of cardiac output transients in response to muscular exercise in man.