Document Detail

Cardiac contractility modulation in the treatment of heart failure: initial results and unanswered questions.
MedLine Citation:
PMID:  21511811     Owner:  NLM     Status:  Publisher    
Despite advances in our understanding of the pathology of heart failure modern conventional pharmacological therapies have proved insufficient. The application of electrical impulses during the refractory period of the cardiac contractile cycle, so-called cardiac contractility modulation (CCM), presents a new therapeutic approach with promising results demonstrated in clinical trials to date. The mechanism by which CCM exerts its effects remains inconclusive with conflicting reports. This article provides a concise review of the experimental and clinical CCM studies conducted to date with particular focus on areas of controversy and unexplored avenues of interest with this novel electrical therapy.
James Winter; Kieran E Brack; G André Ng
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-21
Journal Detail:
Title:  European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology     Volume:  -     ISSN:  1879-0844     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester LE3 9QP, UK.
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