| Cardiac conduction in myotonic dystrophy. | |
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MedLine Citation:
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PMID: 1138549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac conduction abnormalities are frequent in myotonic dystrophy and can result in complete heart block. In a study of 26 patients with myotonic dystrophy, first degree heart block was found to precede clinical presentation of the disease in 7 patients. His bundle electrocardiography in 11 patients demonstrated abnormalities throughout the entire conducting system, even in patients with only first degree heart block. In patients with block of the right bundle branch or anterior fascicle of the left bundle branch, slowing in the remaining fascicles was always present. Therapy of myotonia with procainamide significantly lengthened the P-R interval, and treatment with diphenylhydantoin significantly shortened the P-R interval suggesting that diphenylhydantoin may be preferable for therapy of myotonia in patients with myotonic dystrophy. |
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Authors:
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R C Griggs; R J Davis; D C Anderson; J T Dove |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of medicine Volume: 59 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-09-09 Completed Date: 1975-09-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 37-42 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Electrocardiography Heart / physiopathology* Humans Middle Aged Myotonic Dystrophy / drug therapy, physiopathology* Phenytoin / therapeutic use Procainamide / therapeutic use Quinine / therapeutic use Time Factors |
| Chemical | |
Reg. No./Substance:
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130-95-0/Quinine; 51-06-9/Procainamide; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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