Document Detail

Cardiac conduction in myotonic dystrophy.
MedLine Citation:
PMID:  1138549     Owner:  NLM     Status:  MEDLINE    
Cardiac conduction abnormalities are frequent in myotonic dystrophy and can result in complete heart block. In a study of 26 patients with myotonic dystrophy, first degree heart block was found to precede clinical presentation of the disease in 7 patients. His bundle electrocardiography in 11 patients demonstrated abnormalities throughout the entire conducting system, even in patients with only first degree heart block. In patients with block of the right bundle branch or anterior fascicle of the left bundle branch, slowing in the remaining fascicles was always present. Therapy of myotonia with procainamide significantly lengthened the P-R interval, and treatment with diphenylhydantoin significantly shortened the P-R interval suggesting that diphenylhydantoin may be preferable for therapy of myotonia in patients with myotonic dystrophy.
R C Griggs; R J Davis; D C Anderson; J T Dove
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  59     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-09-09     Completed Date:  1975-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  AIM; IM    
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MeSH Terms
Heart / physiopathology*
Middle Aged
Myotonic Dystrophy / drug therapy,  physiopathology*
Phenytoin / therapeutic use
Procainamide / therapeutic use
Quinine / therapeutic use
Time Factors
Reg. No./Substance:
130-95-0/Quinine; 51-06-9/Procainamide; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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