Document Detail

Cardiac conduction disturbances and ventricular tachycardia after prolonged propofol infusion in an infant.
MedLine Citation:
PMID:  18684267     Owner:  NLM     Status:  MEDLINE    
We report an infant who, after prolonged intravenous propofol infusion for treatment of status epilepticus, developed dramatic cardiac conduction disturbances and tachyarrhythmias in the setting of only mild metabolic acidosis and good ventricular function. Certain electrocardiographic findings were similar to those observed in the Brugada syndrome as well as in adult patients with propofol toxicity who suffered fatal ventricular arrhythmias. This case illustrates that serious arrhythmias can occur during prolonged high-dose propofol infusion in young patients, probably through a direct electrophysiologic membrane effect.
Joshua D C Robinson; Yonathan Melman; Edward P Walsh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  31     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1070-3     Citation Subset:  IM    
Department of Cardiology, Children's Hospital Boston, Boston, Massachusetts, USA.
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MeSH Terms
Anesthetics, Intravenous / administration & dosage,  adverse effects
Brugada Syndrome / chemically induced*,  diagnosis*
Diagnosis, Differential
Infusions, Intravenous / adverse effects
Propofol / administration & dosage*,  adverse effects*
Tachycardia, Ventricular / chemically induced*,  diagnosis*
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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