| Cardiac conduction disturbances and ventricular tachycardia after prolonged propofol infusion in an infant. | |
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MedLine Citation:
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PMID: 18684267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report an infant who, after prolonged intravenous propofol infusion for treatment of status epilepticus, developed dramatic cardiac conduction disturbances and tachyarrhythmias in the setting of only mild metabolic acidosis and good ventricular function. Certain electrocardiographic findings were similar to those observed in the Brugada syndrome as well as in adult patients with propofol toxicity who suffered fatal ventricular arrhythmias. This case illustrates that serious arrhythmias can occur during prolonged high-dose propofol infusion in young patients, probably through a direct electrophysiologic membrane effect. |
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Authors:
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Joshua D C Robinson; Yonathan Melman; Edward P Walsh |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 31 ISSN: 1540-8159 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-07 Completed Date: 2008-10-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 1070-3 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Children's Hospital Boston, Boston, Massachusetts, USA. joshua.robinson@childrens.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthetics, Intravenous
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administration & dosage,
adverse effects Brugada Syndrome / chemically induced*, diagnosis* Diagnosis, Differential Humans Infant Infusions, Intravenous / adverse effects Male Propofol / administration & dosage*, adverse effects* Tachycardia, Ventricular / chemically induced*, diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Intravenous; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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