Document Detail

Cardiac conduction abnormalities in patients with breast cancer undergoing high-dose chemotherapy and stem cell transplantation.
MedLine Citation:
PMID:  10673678     Owner:  NLM     Status:  MEDLINE    
Cardiac toxicities in 39 consecutive patients with breast cancer receiving high-dose chemotherapy (HDC) with stem cell transplantation were reviewed. All 39 patients received various anthracycline-containing regimens in adjuvant settings and/or for metastatic disease before HDC. As a cytoreductive regimen, all received cyclophosphamide 2000 mg/m2 and thiotepa 200 mg/m2 for 3 consecutive days. No immediate fatal toxicities were observed, but one patient developed chronic congestive heart failure and two had transient left ventricular dysfunction. Pericardial effusion was observed in another three patients. ST-T abnormalities during HDC were observed in two patients and arrhythmias were observed in nine, four of which occurred during stem cell infusion (SCI). There were three atrial arrhythmias, two ventricular arrhythmias, and four atrioventricular (AV)-block episodes. Two patients developed advanced and complete AV-block with an asystolic pause. Notably, three patients experienced AV-block with uncontrolled vomiting. No relationship was observed between the cumulative dose of anthracycline and cardiac toxicities during HDC. These results suggest that abnormalities in the conduction system during HDC may be more frequent than previously reported. Vagal reflex secondary to emesis may play an important role in the development of AV-block. Bone Marrow Transplantation (2000) 25, 185-189.
M Ando; T Yokozawa; J Sawada; Y Takaue; K Togitani; N Kawahigashi; M Narabayashi; K Takeyama; R Tanosaki; S Mineishi; Y Kobayashi; T Watanabe; I Adachi; K Tobinai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bone marrow transplantation     Volume:  25     ISSN:  0268-3369     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-20     Completed Date:  2000-03-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  IM    
Department of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  adverse effects*,  pharmacology
Arrhythmias, Cardiac / chemically induced,  etiology
Breast Neoplasms / complications,  drug therapy,  therapy*
Combined Modality Therapy / adverse effects
Cyclophosphamide / administration & dosage,  adverse effects
Doxorubicin / administration & dosage,  adverse effects
Heart Block / chemically induced,  etiology
Heart Conduction System / drug effects,  physiopathology*
Heart Diseases / chemically induced,  etiology*,  physiopathology
Hematopoietic Stem Cell Transplantation / adverse effects*
Middle Aged
Nausea / chemically induced,  etiology
Retrospective Studies
Thiotepa / administration & dosage,  adverse effects
Vomiting / chemically induced,  etiology
Reg. No./Substance:
23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 52-24-4/Thiotepa

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