Document Detail

Cardiac complications in thalassemia: noninvasive detection methods and new directions in the clinical management.
MedLine Citation:
PMID:  15030271     Owner:  NLM     Status:  MEDLINE    
The natural history of thalassemia has shown substantial change during these years. This applies for each aspect of the pathology (for example, endocrinological, hepatological and psychological) and also for the pathology that has presented and still presents the main cause of death: myocardial dysfunction. In this review, the pathophysiology of cardiac complications, possible role of myocarditis, new knowledge on pathogenesis, and noninvasive detection methods for iron overload in the heart are pointed out. Prophylaxis of cardiomyopathy and new therapy strategies of myocardial dysfunction, including the impact of the new chelation treatment, are discussed.
Luigi Mancuso; Gaetano Panzarella; Tommaso Vincenzo Bartolotta; Massimo Midiri; Disma Renda; Aurelio Maggio
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  1     ISSN:  1477-9072     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2004-03-26     Completed Date:  2004-04-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  439-52     Citation Subset:  IM    
Department of Cardiology, A.O.V. Cervello Hospital, Palermo, Italy.
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MeSH Terms
Cardiomyopathies / complications,  diagnosis*,  pathology,  prevention & control*,  ultrasonography
Magnetic Resonance Imaging
Thalassemia / complications*

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