Document Detail

Cardiac complication from use of cocaine and phenylephrine in nasal septoplasty.
MedLine Citation:
PMID:  7772323     Owner:  NLM     Status:  MEDLINE    
Cocaine hydrochloride is widely used as a topical anesthetic for otolaryngologic surgery. Cardiovascular complications, including myocardial injury, are well-documented side effects of illicit cocaine use. We describe a 23-year-old woman without coronary artery disease who had an acute non-Q-wave myocardial infarction and stunned myocardium after receiving topical phenylephrine hydrochloride and cocaine anesthesia for elective nasal septoplasty. These cases are rare; however, we hope to heighten the awareness of the potential lethal complications of using cocaine, phenylephrine, or the combination of both as topical anesthetics in otolaryngologic practice.
M Ashchi; H P Wiedemann; K B James
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  121     ISSN:  0886-4470     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-07     Completed Date:  1995-07-07     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  681-4     Citation Subset:  AIM; IM    
Mount Sinai Medical Center/MetroHealth Medical Center, Cleveland, Ohio, USA.
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MeSH Terms
Administration, Topical
Anesthesia, Local / adverse effects*
Cocaine / administration & dosage,  adverse effects*
Middle Aged
Myocardial Infarction / chemically induced*
Myocardial Stunning / chemically induced*
Nasal Septum / surgery*
Phenylephrine / administration & dosage,  adverse effects*
Surgical Procedures, Elective
Reg. No./Substance:
50-36-2/Cocaine; 59-42-7/Phenylephrine
Comment In:
Arch Otolaryngol Head Neck Surg. 1996 Feb;122(2):207-8   [PMID:  8630221 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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