Document Detail

Cardiac candidiasis in cancer patients.
MedLine Citation:
PMID:  657099     Owner:  NLM     Status:  MEDLINE    
Histologically proven infection of the heart by Candida organisms occurred in 17 (10%) of 168 cancer patients with candidiasis studied at necropsy. All 17 patients were among the 85 patients with disseminated Candida infection; none of the 83 patients with localized candidiasis had involvement of the heart. Abscesses in the myocardium were present by histologic examination in all 17 patients and in 8 were evident on gross inspection as well. The mural endocardium was also affected in 5 patients from direct extension of a myocardial abscess. The valves were uninvolved. Pericardial infection was detected in 2 patients. The 17 patients with cardiac Candida infection had a higher frequency of positive premortem blood and cerebrospinal fluid cultures and of presence of Candida in the heart's blood than did the 68 patients with disseminated candidiasis but without involvement of the heart. Symptoms or signs of cardiac dysfunction resulting from the cardiac Candida infection were not readily detected in any patient. The clinical and pathologic features of cardiac candidiasis in cancer patients are distinct from those observed in Candida endocarditis.
D C Ihde; W C Roberts; K C Marr; H D Brereton; W P McGuire; A S Levine; R C Young
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  41     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2364-71     Citation Subset:  AIM; IM    
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MeSH Terms
Candidiasis / etiology*,  pathology
Diagnosis, Differential
Endocarditis / etiology,  pathology
Endocardium / pathology
Heart Diseases / etiology*,  pathology
Myocardium / pathology
Neoplasms / complications*
Pericardium / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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