| Cardiac beta1-adrenoceptor autoantibodies in human heart disease: rationale and design of the Etiology, Titre-Course, and Survival (ETiCS) Study. | |
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MedLine Citation:
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PMID: 20494925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Evidence for a pathophysiologic relevance of autoimmunity in human heart disease has substantially increased over the past years. Conformational autoantibodies stimulating the cardiac beta1-adrenoceptor (beta1-aabs) are considered of importance in heart failure development and clinical pilot studies have shown their prognostic significance in human 'idiopathic' cardiomyopathy. METHODS: We recently developed a novel highly sensitive fluorescence-based functional assay to detect stimulating beta1-aabs. We will use this method to assess Etiology, Titre-Course, and effect on Survival (ETiCS) of beta1-aabs in a prospective multicentre study with serial follow-up of patients after a first acute myocarditis or myocardial infarction. Several European core laboratories will jointly study the hypothesis that both disorders may trigger autoimmune reactions leading to the generation of beta1-aabs and/or other heart-directed aabs. Further, sera from healthy controls and well-characterized patient cohorts with dilated, ischaemic, or hypertensive cardiomyopathy will be analysed retrospectively for beta1-aab prevalence, incidence, persistence, and/or clearance. CONCLUSION: ETiCS is so far the largest clinical diagnostic study projected to address cardiac autoimmunity. It attempts to unravel the pathophysiology of cardiac autoantibody formation and persistence/clearance. ETiCS will enhance current knowledge on autoimmunity in human heart disease and promote endeavours to develop novel therapies targeting cardiac aabs. |
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Authors:
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Nikolas Deubner; Dominik Berliner; Angela Schlipp; Götz Gelbrich; Alida L P Caforio; Stephan B Felix; Michael Fu; Hugo Katus; Christiane E Angermann; Martin J Lohse; Georg Ertl; Stefan Störk; Roland Jahns; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-21 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-25 Completed Date: 2010-10-01 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 753-62 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, Centre of Cardiovascular Medicine, University of Würzburg, University Hospital Würzburg, Klinikstrasse 6-8, 97070 Würzburg, Germany. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibody Specificity
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immunology Autoantibodies / immunology* Autoimmunity / immunology* Cardiomyopathy, Dilated / immunology* Humans Immunoassay / methods Multicenter Studies as Topic Myocardial Infarction / immunology* Myocarditis / immunology* Myocardium / immunology* Patient Selection Receptors, Adrenergic, beta-1 / immunology* Research Design* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Receptors, Adrenergic, beta-1 |
| Investigator | |
Investigator/Affiliation:
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Georg Ertl / ; Roland Jahns / ; Christiane E Angermann / ; Stefan Störk / ; Nikolas Deubner / ; Dominik Berliner / ; Martin J Lohse / ; Valérie Jahns / ; Angela Schlipp / ; Markus Löffler / ; Oana Brosteanu / ; Götz Gelbrich / ; Christiane Prettin / ; Birgit Saumer / ; Reinhard Kandolf / ; Karin Klingel / ; Wolfgang Bauer / ; Gerhard Herrmann / ; Judith Stürmer / ; Matthias Pauschinger / ; René Lerch / ; Heribert Schunkert / ; Thomas Hünig / ; Thomas Kerkau / ; Niklas Beyersdorf / ; Vladimir Kocoski / ; Alida L P Caforio / ; Stephan B Felix / ; Michael Fu / ; Thomas J Dengler / ; Ralf Dechend / ; Rainer Dietz / ; Felix Mehrhof / ; Cemil Ozcelik / ; Maximilian Posch / ; Hans-Peter Schultheiss / ; Uwe Kühl / ; Ralf Dechend / ; Dominik N Müller / ; Raimund Erbel / ; Gerd Hasenfuss / ; Burkert Pieske / ; Rolf Wachter / ; Frank Edelmann / ; Michael Fu / ; Stephan B Felix / ; Alexander Staudt / ; Hugo Katus / ; Ziya Kaya / ; Bernhard Maisch / ; Sabine Pankuweit / ; Alida A L Caforio / ; Sabino Iliceto / ; Udo Sechtem / ; Tim Schäufele / ; Hannah Fsadni / ; Christoph Nienaber / ; Mathias Rauchhaus / ; Georg Ertl / ; Roland Jahns / ; Christiane E Angermann / ; Stefan Störk / ; Stefan Frantz / ; Oliver Ritter / ; Dominik Berliner / ; Nikolas Deubner / ; Christoph Wanner / ; Frank Breunig / ; Vera Krane / ; Valérie Jahns / ; Martin J Lohse / ; Viacheslav O Nikolaev / ; Angela Schlipp / ; Alexander Zürn / ; Thomas Hünig / ; Thomas Kerkau / ; Beyersdorf Niklas / ; Vladimir Kocoski / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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