Document Detail

Cardiac basal metabolism.
MedLine Citation:
PMID:  11564278     Owner:  NLM     Status:  MEDLINE    
We endeavor to show that the metabolism of the nonbeating heart can vary over an extreme range: from values approximating those measured in the beating heart to values of only a small fraction of normal--perhaps mimicking the situation of nonflow arrest during cardiac bypass surgery. We discuss some of the technical issues that make it difficult to establish the magnitude of basal metabolism in vivo. We consider some of the likely contributors to its magnitude and point out that the biochemical reasons for a sizable fraction of the heart's basal ATP usage remain unresolved. We consider many of the physiological factors that can alter the basal metabolic rate, stressing the importance of substrate supply. We point out that the protective effect of hypothermia may be less than is commonly assumed in the literature and suggest that hypoxia and ischemia may be able to regulate basal metabolic rate, thus making an important contribution to the phenomenon of cardiac hibernation.
C L Gibbs; D S Loiselle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  51     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-09-20     Completed Date:  2002-01-08     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  399-426     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, Nursing and Health Sciences, Monash University, PO Box 13F, Monash University, Victoria 3800, Australia.
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MeSH Terms
Adenosine Triphosphate / metabolism*
Basal Metabolism / physiology*
Culture Techniques
Heart / physiology*
Myocardial Ischemia
Reg. No./Substance:
56-65-5/Adenosine Triphosphate

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