| Cardiac baroreflex sensitivities in conscious, unrestrained, Long Evans and Brattleboro rats. | |
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MedLine Citation:
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PMID: 3192899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac baroreflex sensitivity (BRS; i.e. the slope of the line relating change in pulse interval to change in systemic arterial pressure) was assessed in response to an increase in mean blood pressure (MBP) evoked by methoxamine or a decrease evoked by sodium nitroprusside. Measurements were made in Long Evans (i.e. control) and in Brattleboro (i.e. vasopressin (AVP)-deficient) rats, following acute and chronic intravascular catheterization, and in water-replete and water-deprived states (the latter designed to reduce plasma volume and activate AVP-dependent mechanisms (in Long Evans rats]. There were no differences between the corresponding values for cardiac BRS in Long Evans and Brattleboro rats. Furthermore, water deprivation caused no significant changes in cardiac BRS in either strain. These results do not support the claim that absence of endogenous AVP in Brattleboro rats is associated with marked impairment of cardiac BRS, and indicate that chronic changes in circulating AVP do not cause systematic changes in cardiac BRS. |
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Authors:
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S M Gardiner; T Bennett |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of the autonomic nervous system Volume: 23 ISSN: 0165-1838 ISO Abbreviation: J. Auton. Nerv. Syst. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1989-01-09 Completed Date: 1989-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8003419 Medline TA: J Auton Nerv Syst Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 213-9 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heart / drug effects, innervation*, physiology Male Methoxamine / pharmacology Nitroprusside / pharmacology Pressoreceptors / drug effects, physiology* Rats Rats, Brattleboro / physiology* Rats, Mutant Strains / physiology* Time Factors Water Deprivation / physiology |
| Chemical | |
Reg. No./Substance:
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15078-28-1/Nitroprusside; 390-28-3/Methoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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