Document Detail

Cardiac autonomic dysfunction in obese subjects.
MedLine Citation:
PMID:  2736876     Owner:  NLM     Status:  MEDLINE    
1. The prevalence of cardiac autonomic alterations was evaluated in 23 obese subjects with body mass index 37.2 +/- 3.03 kg/m2 (mean +/- SD), compared with 78 controls with body mass index 22.5 +/- 2.6 kg/m2 (P less than 0.001). 2. Cardiac autonomic function was assessed by four standard tests (heart rate response to deep breathing and to the Valsalva manoeuvre, systolic blood pressure fall after standing and diastolic pressure rise during handgrip) and by the cross-correlation test, a new method of computerized analysis of respiratory sinus arrhythmia based on spectral analysis of electrocardiographic and respiratory signal. 3. Considering tests indicative of parasympathetic function, only the heart rate response to the deep breathing and the cross-correlation test were significantly lower in the obese than in the control group [deep breathing = 13.95 +/- 8.65 beats/min (mean +/- SD) vs 24.5 +/- 7.65, P less than 0.001; cross-correlation 4.28 +/- 0.74 units vs 5.14 +/- 0.63, P less than 0.001]. Deep breathing and/or cross-correlation were abnormal in 10 (43.5%) obese subjects (deep breathing: seven subjects, cross-correlation: eight subjects). No significant difference between groups was found for the response to the Valsalva manoeuvre: the Valsalva ratio was 1.69 +/- 0.45 in obese subjects and 1.88 +/- 0.33 in controls (P = NS). The Valsalva ratio was abnormal in three obese subjects. 4. No significant differences were found between groups for tests indicative of sympathetic function.(ABSTRACT TRUNCATED AT 250 WORDS)
M Rossi; G Marti; L Ricordi; G Fornasari; G Finardi; P Fratino; L Bernardi
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  76     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-31     Completed Date:  1989-07-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  567-72     Citation Subset:  IM    
Department of Internal Medicine, IRCCS Policlinico San Matteo, University of Pavia, Italy.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Blood Pressure
Heart / physiopathology*
Heart Rate
Isometric Contraction
Middle Aged
Obesity / physiopathology*
Valsalva Maneuver

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