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Cardiac autonomic activity and blood pressure among Inuit children exposed to mercury.
MedLine Citation:
PMID:  23227484     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Studies conducted in the Faeroe Islands and Japan suggest a negative impact of mercury on heart rate variability (HRV) among children while the results regarding blood pressure (BP) are less consistent.
OBJECTIVE: To assess the impact of mercury on HRV and BP among Nunavik Inuit children.
METHODS: A cohort of 226 children was followed from birth to 11 years old. Mercury concentration in cord blood and in blood and hair at 11 years old were used as markers of prenatal and childhood exposure, respectively. HRV was measured using ambulatory 2 h-Holter monitoring while BP was measured through a standardized protocol. Simple regression was used to assess the relationship of mercury to BP and HRV parameters. Multiple linear regressions were performed adjusting for covariates such as age, sex, birth weight, body mass index (BMI), height, total n-3 fatty acids, polychlorinated biphenyls (PCB 153), lead, selenium and maternal smoking during pregnancy.
RESULTS: Median cord blood mercury and blood mercury levels at 11 years old were 81.5 nmoL/L (IQR:45.0–140.0) and 14.5 nmol/L (IQR: 7.5–28.0), respectively. After adjusting for the covariates, child blood mercury was associated with low frequency (LF) (b = 0.21, p = 0.05), the standard deviation of R–R intervals (SDNN) (b = 0.26, p = 0.02), the standard deviation of R–R intervals measured over 5 min periods (SDANN) (b = 0.31, p = 0.01) and the coefficient of variation of R–R intervals (CVRR) (b = 0.06,p = 0.02). No significant association was observed with BP.
CONCLUSION: Mercury exposure during childhood seems to affect HRV among Nunavik Inuit children at school age.
Authors:
Beatriz Valera; Gina Muckle; Paul Poirier; Sandra W Jacobson; Joseph L Jacobson; Eric Dewailly
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurotoxicology     Volume:  33     ISSN:  1872-9711     ISO Abbreviation:  Neurotoxicology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905589     Medline TA:  Neurotoxicology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1067-74     Citation Subset:  IM    
Affiliation:
CHUQ Medical Research Center. Quebec, Canada.
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