Document Detail

Cardiac aspergillosis in patients with acquired immunodeficiency syndrome: a case report and review of the literature.
MedLine Citation:
PMID:  15794676     Owner:  NLM     Status:  MEDLINE    
Cardiac aspergillosis is uncommon in patients with acquired immunodeficiency syndrome (AIDS) in the absence of open heart surgery. We report a unique case of a 62-year-old man with AIDS who developed Aspergillus pancarditis with Aspergillus vegetations on mitral valve without evidence of pulmonary aspergillosis. There was extensive embolization to the brain and multiple foci of Aspergillus infection in kidneys and adrenal glands. There are only 10 documented cases of cardiac aspergillosis in the literature (1966-2003) in severely immunocompromised AIDS patients with CD4 T-lymphocyte counts ranging from 10 to 121 cells/muL. The cardiac aspergillosis could result from invasive pulmonary aspergillosis, either by hematogenous dissemination or by direct invasion, and skin Aspergillus infection can be carried through the bloodstream to the right heart in intravenous drug abusers. Most of the reported cases of cardiac aspergillosis were diagnosed at autopsy. Mortality among AIDS patients with cardiac aspergillosis is 100%, despite appropriate therapy.
Linjun Xie; Wondwossen Gebre; Katarina Szabo; Jen H Lin
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  129     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-29     Completed Date:  2005-10-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  511-5     Citation Subset:  AIM; IM    
Department of Pathology, Nassau University Medical Center, East Meadow, NY 11554, USA.
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MeSH Terms
AIDS-Related Opportunistic Infections / diagnosis,  microbiology*,  pathology*
Acquired Immunodeficiency Syndrome / complications
Aspergillosis / complications,  diagnosis,  pathology*
Endocarditis / microbiology,  pathology
Fatal Outcome
Heart Diseases / complications,  diagnosis,  microbiology*,  pathology*
Middle Aged
Myocarditis / microbiology,  pathology
Pericarditis / microbiology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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