| Cardiac arrhythmias in neonates receiving lidocaine as anticonvulsive treatment. | |
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MedLine Citation:
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PMID: 15309624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lidocaine has been used in neonates as an effective drug in controlling neonatal seizures not responding to traditional anticonvulsant therapy. Little is known about the effect of lidocaine on heart rate or occurrence of cardiac arrhythmias in neonates. The purpose of the present study was to assess the incidence of cardiac arrhythmias associated with lidocaine use for neonatal seizures. A retrospective review was performed in 207 neonates who received lidocaine for treatment of neonatal seizures. All were given a loading dose of 2 mg/kg in 10 min followed by a continuous infusion of 6 mg/kg per h, tailed off over the next 48 h. A total of ten (4,8%) infants developed cardiac arrhythmias during lidocaine infusion. In five infants a bradycardia developed, associated with a prolonged QRS complex in one. In one infant a tachycardia was seen following the bolus administration. In the other four an irregular heart rate was noted. In eight infants the arrhythmias disappeared immediately following discontinuation of lidocaine. In two infants, with severe encephalopathy, who died, the association was not so clear. CONCLUSION: The present study demonstrates that continuous cardiac monitoring of neonates who receive lidocaine for neonatal seizures is indicated, as there is a risk to develop cardiac arrhythmias. Lidocaine should be discontinued immediately when a cardiac arrhythmia occurs. Lidocaine should not be given to patients with a congenital heart disease and to infants who have already been treated with diphantoine. |
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Authors:
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Linda G M van Rooij; Mona C Toet; Karin M A Rademaker; Floris Groenendaal; Linda S de Vries |
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Publication Detail:
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Type: Journal Article Date: 2004-08-07 |
Journal Detail:
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Title: European journal of pediatrics Volume: 163 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-25 Completed Date: 2005-03-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
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Languages: eng Pagination: 637-41 Citation Subset: IM |
Affiliation:
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Department of Neonatology, University Medical Centre Utrecht/Wilhelmina Children's Hospital, KE 04.123.1, PO Box 85090, 3508 AB, Utrecht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects*,
therapeutic use Arrhythmias, Cardiac / chemically induced* Electrocardiography Heart Rate / drug effects Humans Infant, Newborn Lidocaine / adverse effects*, therapeutic use Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 137-58-6/Lidocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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