Document Detail

Cardiac arrhythmias during occupational exposure to fluorinated hydrocarbons.
MedLine Citation:
PMID:  2310718     Owner:  NLM     Status:  MEDLINE    
The effects of occupational exposure to chlorodifluoromethane (FC 22) and dichlorodifluoromethane (FC 12) on cardiac rhythm were examined. The subjects were six men who repaired refrigerators (age 31-56, mean 46 years) and a control group of six plumbers (age 29-54, mean 45 years). Ambulatory electrocardiograms (ECG) were recorded for 24 hours on the day of exposure and on a control day. The ECG tapes were automatically analysed with a Reynolds pathfinder 3 apparatus and all aberrant complexes recorded by the machine were checked. One person read all the tapes without knowing whether or not they were recorded during exposure. The number of ventricular ectopic beats were compared between the day of exposure and the control day and with the tape of the control. In addition, the number of ventricular ectopic beats during exposure was compared with the number occurring during the rest of the day. The concentrations of fluorocarbons were measured in four instances. High peak concentrations of fluorocarbons (1300-10,000 cm3/m3) were measured during refrigerator repair work. No clear connection between fluorocarbons and cardiac arrhythmia was found, although one subject had several ventricular ectopic beats which may have been connected with exposure.
M Antti-Poika; J Heikkilä; L Saarinen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of industrial medicine     Volume:  47     ISSN:  0007-1072     ISO Abbreviation:  Br J Ind Med     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-04-18     Completed Date:  1990-04-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370637     Medline TA:  Br J Ind Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  138-40     Citation Subset:  IM    
Institute of Occupational Health, Helsinki, Finland.
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MeSH Terms
Arrhythmias, Cardiac / chemically induced*,  physiopathology
Chlorofluorocarbons, Methane / adverse effects*
Electrocardiography, Ambulatory
Heart Ventricles / physiopathology
Middle Aged
Occupational Diseases / chemically induced*
Reg. No./Substance:
0/Chlorofluorocarbons, Methane; 75-45-6/fluorocarbon 22; 75-71-8/dichlorodifluoromethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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