| Cardiac arrhythmias and conduction disturbances in autoimmune rheumatic diseases. | |
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MedLine Citation:
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PMID: 16980722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rhythm and conduction disturbances and sudden cardiac death (SCD) are important manifestations of cardiac involvement in autoimmune rheumatic diseases (ARDs). In patients with rheumatoid arthritis (RA), a major cause of SCD is atherosclerotic coronary artery disease, leading to acute coronary syndrome and ventricular arrhythmias. In systemic lupus erythematosus (SLE), sinus tachycardia, atrial fibrillation and atrial ectopic beats are the major cardiac arrhythmias. In some cases, sinus tachycardia may be the only manifestation of cardiac involvement. The most frequent cardiac rhythm disturbances in systemic sclerosis (SSc) are premature ventricular contractions (PVCs), often appearing as monomorphic, single PVCs, or rarely as bigeminy, trigeminy or pairs. Transient atrial fibrillation, flutter or paroxysmal supraventricular tachycardia are also described in 20-30% of SSc patients. Non-sustained ventricular tachycardia was described in 7-13%, while SCD is reported in 5-21% of unselected patients with SSc. The conduction disorders are more frequent in ARD than the cardiac arrhythmias. In RA, infiltration of the atrioventricular (AV) node can cause right bundle branch block in 35% of patients. AV block is rare in RA, and is usually complete. In SLE small vessel vasculitis, the infiltration of the sinus or AV nodes, or active myocarditis can lead to first-degree AV block in 34-70% of patients. In contrast to RA, conduction abnormalities may regress when the underlying disease is controlled. In neonatal lupus, 3% of infants whose mothers are antibody positive develop complete heart block. Conduction disturbances in SSc are due to fibrosis of sinoatrial node, presenting as abnormal ECG, bundle and fascicular blocks and occur in 25-75% of patients. |
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Authors:
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P M Seferović; A D Ristić; R Maksimović; D S Simeunović; G G Ristić; G Radovanović; D Seferović; B Maisch; M Matucci-Cerinic |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Rheumatology (Oxford, England) Volume: 45 Suppl 4 ISSN: 1462-0332 ISO Abbreviation: Rheumatology (Oxford) Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-18 Completed Date: 2007-11-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883501 Medline TA: Rheumatology (Oxford) Country: England |
Other Details:
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Languages: eng Pagination: iv39-42 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Institute for Cardiovascular Diseases of the Clinical Center of Serbia, Koste Todorovica 8, 11000 Belgrade, Serbia. eseferov@eunet.yu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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complications*,
physiopathology,
therapy Autoimmune Diseases / complications*, physiopathology Electrocardiography* Heart Conduction System / physiopathology* Humans Rheumatic Diseases / complications*, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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