| Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. | |
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MedLine Citation:
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PMID: 20688187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inherited Long QT Syndrome (LQTS), a cardiac arrhythmia that predisposes to the often lethal ventricular fibrillation, is commonly linked to mutations in KCNQ1. The KCNQ1 voltage-gated K(+) channel α subunit passes ventricular myocyte K(+) current that helps bring a timely end to each heart-beat. KCNQ1, like many K(+) channel α subunits, is regulated by KCNE β subunits, inherited mutations in which also associate with LQTS. KCNQ1 and KCNE mutations are also associated with atrial fibrillation. It has long been known that thyroid status strongly influences cardiac function, and that thyroid dysfunction causes abnormal cardiac structure and rhythm. We recently discovered that KCNQ1 and KCNE2 form a thyroid-stimulating hormone-stimulated K(+) channel in the thyroid that is required for normal thyroid hormone biosynthesis. Here, we review this novel genetic link between cardiac and thyroid physiology and pathology, and its potential influence upon future therapeutic strategies in cardiac and thyroid disease. |
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Authors:
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Kerry Purtell; Torsten K Roepke; Geoffrey W Abbott |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-08-03 |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: 42 ISSN: 1878-5875 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-01-18 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1767-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / genetics*, metabolism, physiopathology* Atrial Fibrillation / genetics, metabolism, physiopathology Humans Hyperthyroidism / genetics, metabolism, physiopathology Hypothyroidism / genetics, metabolism, physiopathology KCNQ1 Potassium Channel / genetics Long QT Syndrome / genetics, metabolism, physiopathology Potassium Channels, Voltage-Gated / genetics Thyroid Diseases / genetics*, metabolism, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL079275/HL/NHLBI NIH HHS; R01 HL079275/HL/NHLBI NIH HHS; R01HL101190/HL/NHLBI NIH HHS; T32GM073546/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/KCNQ1 Potassium Channel; 0/Potassium Channels, Voltage-Gated |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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