Document Detail

Cardiac arrest after intracisternal papaverine instillation during intracranial aneurysm surgery. Case report.
MedLine Citation:
PMID:  19961315     Owner:  NLM     Status:  MEDLINE    
Cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage is still a leading cause of morbidity and death. This 50-year-old man underwent surgery for aneurysm clipping. After the aneurysm was clipped, papaverine was instilled into the surgical area. Bradycardia, hypotension, and sinus arrest developed in the first minute after applying the papaverine. Thus, the authors concluded that the application of papaverine to the surgical area can result in fatal bradycardia and hypotension.
Bulent Baltaci; Hulya Basar; Ayse Ozcan; Yusuf Gulhan; Cihan Sedat Aytunur
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  113     ISSN:  1933-0693     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  760-2     Citation Subset:  AIM; IM    
Department of Anaesthesiology and Reanimation, Ankara Training and Research Hospital, Ministry of Health, Ankara, Turkey.
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MeSH Terms
Bradycardia / chemically induced
Cisterna Magna
Fatal Outcome
Glasgow Coma Scale
Heart Arrest / chemically induced*
Hemodynamics / physiology
Hypotension / chemically induced
Intracranial Aneurysm / surgery*
Middle Aged
Neurosurgical Procedures
Papaverine / administration & dosage*,  adverse effects*
Sinus Arrest, Cardiac / chemically induced
Subarachnoid Hemorrhage / surgery
Vasodilator Agents / administration & dosage*,  adverse effects*
Reg. No./Substance:
0/Vasodilator Agents; 58-74-2/Papaverine

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