Document Detail


Cardiac applications of EPR imaging.
MedLine Citation:
PMID:  15366025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review summarizes the development and application of a variety of EPR imaging modalities including spatial, spectral-spatial (spectroscopic), gated-imaging and oxygen mapping to cardiovascular studies. It has been hypothesized that free radical metabolism, oxygenation and nitric oxide generation in biological organs such as the heart may vary over the spatially defined tissue structure. We have developed instrumentation optimized for 3D spatial and 3D or 4D spectral-spatial imaging of free radicals at 1.2 GHz. Using this instrumentation high quality 3D spectral-spatial imaging of nitroxyl (nitroxide) metabolism was performed, as well as spatially localized measurements of oxygen concentrations, based on the oxygen-dependent line-broadening of the EPR spectrum. Both exogenously infused probes and endogenous radicals were used to obtain the images. It is demonstrated that the EPR imaging is a powerful tool which can provide unique information regarding the spatial localization of free radicals, oxygen and nitric oxide in biological organs and tissues.
Authors:
Periannan Kuppusamy; Jay L Zweier
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  NMR in biomedicine     Volume:  17     ISSN:  0952-3480     ISO Abbreviation:  NMR Biomed     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2005-02-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  226-39     Citation Subset:  IM    
Copyright Information:
Copyright 2004 John Wiley & Sons, Ltd.
Affiliation:
Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, and Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA. kuppusamy-1@medctr.osu.edu
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Biological Markers / metabolism
Electron Spin Resonance Spectroscopy / instrumentation,  methods*
Humans
Image Interpretation, Computer-Assisted / methods
Imaging, Three-Dimensional / instrumentation,  methods
Mice
Myocardial Ischemia / diagnosis,  metabolism*,  pathology*
Myocardium / metabolism*,  pathology*
Nitric Oxide / metabolism*
Oxygen / metabolism*
Tissue Distribution
Grant Support
ID/Acronym/Agency:
CA 102264/CA/NCI NIH HHS; CA 78886/CA/NCI NIH HHS; EB00306/EB/NIBIB NIH HHS; EB004031/EB/NIBIB NIH HHS; EB00890/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 10102-43-9/Nitric Oxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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