| Cardiac amyloidosis responding to bortezomib: case report and review of literature. | |
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MedLine Citation:
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PMID: 20676282 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We report a case of a 53-year old patient with symptoms of congestive heart failure in whom a restrictive cardiomyopathy and a kappa-chain monoclonal gammopahty were diagnosed. Treatment with eight cycles of Bortezomib, a proteasome inhibitor, resulted in a significant regression of myocardial amyloid deposition and a notable clinical and hemodynamic improvement. Over the last few years, the management of cardiac amyloidosis has taken advantage of many of the advances of the chemotherapeutic regimens, as well as the wider availability of stem cell transplantation. The management of cardiac amyloidosis is also expected to evolve and improve with the better understanding of the specific mechanisms of amyloidogenesis and myocardial deposition. This will probably make certain molecules targeting specific sites in this process, as potentially effective and minimally toxic compared therapy with the currently used ones. In this article, we describe one of the first reported cases of cardiac amyloidosis, successfully treated with Bortezomib. We describe and discuss the mechanisms of action of Bortezomib and provide a detailed review of cardiac amyloidosis, from pathophysiology to diagnosis and treatment. |
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Authors:
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Edriss Charaf; Said B Iskandar; Ashley Blevins; Bernard Abi-Saleh; Stephen Fahrig |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current cardiology reviews Volume: 5 ISSN: 1875-6557 ISO Abbreviation: Curr Cardiol Rev Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101261935 Medline TA: Curr Cardiol Rev Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 228-36 Citation Subset: - |
Affiliation:
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Division of Cardiology, University of South Alabama, Mobile, Alabama, USA. |
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