Document Detail

Cardiac amyloidosis in a patient with multiple myeloma: a case report and review of literature.
MedLine Citation:
PMID:  19177424     Owner:  NLM     Status:  MEDLINE    
We report a case of a 52-year-old man with multiple myeloma and rapidly progressive heart failure who died unexpectedly from a probable arrhythmia. Postmortem examination revealed infiltrative amyloid cardiomyopathy, a rare cause of predominantly diastolic myocardial disease. Cardiac amyloidosis should be considered in any patient presenting with congestive heart failure, preserved systolic function, and a discrepancy between a low QRS voltage on electrocardiography and an apparent left ventricular hypertrophy on sonogram. The pattern of left ventricular diastolic dysfunction changes during the course of amyloidosis and the classically described restrictive physiology occurs only in advanced stages of the disease.
David Sedaghat; Ramzan M Zakir; Jin Choe; Marc Klapholz; Muhamed Saric
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of clinical ultrasound : JCU     Volume:  37     ISSN:  1097-0096     ISO Abbreviation:  J Clin Ultrasound     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-07-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401663     Medline TA:  J Clin Ultrasound     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Copyright Information:
2009 Wiley Periodicals, Inc.
Department of Medicine, New Jersey Medical School, 185 South Orange Avenue, I-538, Newark, NJ 07103, USA.
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MeSH Terms
Amyloidosis / complications*,  diagnosis,  genetics*
Arrhythmias, Cardiac / complications
Cardiomyopathy, Restrictive / complications*,  diagnosis,  genetics*
Fatal Outcome
Heart Failure / complications
Heart Ventricles / ultrasonography
Hypertrophy, Left Ventricular / complications,  ultrasonography
Middle Aged
Multiple Myeloma / complications*,  drug therapy
Ultrasonography, Doppler

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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