Document Detail

Cardiac amyloidosis: MR imaging findings and T1 quantification, comparison with control subjects.
MedLine Citation:
PMID:  17520735     Owner:  NLM     Status:  MEDLINE    
In cardiac amyloidosis an interstitial deposition of amyloid fibrils causes concentric thickening of the atrial and ventricular walls. We describe the results of tissue characterization of the myocardium by T1 quantification and MRI findings in a patient with cardiac amyloidosis. The T1 time of the myocardium was elevated compared to that in individuals without amyloidosis. The T1 time of the myocardium was 1387 +/- 63 msec (mean value obtained from four measurements +/- standard deviation [SD]) in the patient with cardiac amyloidosis, while the reference value obtained from the myocardium of 10 individuals without known myocardial disease was 1083 +/- 33 msec (mean value +/- SD). In combination with other MR findings suggestive of amyloidosis, such as homogeneous thickening of the ventricular and atrial walls, thickening of the valve leaflets, restrictive filling pattern, and reduction of systolic function, T1 quantification may increase diagnostic confidence.
Gabriele A Krombach; Christa Hahn; Maren Tomars; Arno Buecker; Armin Grawe; Rolf W Günther; Harald P Kühl
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  25     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1283-7     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Department of Diagnostic Radiology, University Hospital, Pauwelsstrasse 30, 52057 Aachen, Germany.
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MeSH Terms
Amyloidosis / diagnosis*
Cardiomyopathies / diagnosis*
Case-Control Studies
Contrast Media
Diagnosis, Differential
Echocardiography, Doppler
Gadolinium DTPA / diagnostic use
Magnetic Resonance Imaging / methods*
Middle Aged
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

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