Document Detail

Cardiac aldosterone in subjects with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  17318792     Owner:  NLM     Status:  MEDLINE    
Left ventricular (LV) hypertrophy in subjects with hypertrophic cardiomyopathy (HCM) is variable, suggesting a role for modifying factors. Here, we determined whether aldosterone modulates hypertrophy in HCM. Cardiac and/or plasma aldosterone were measured in organ donors and HCM patients. The effect of the aldosterone synthase ( CYP11B2 ) C-344T polymorphism on LV mass index (LVMI) and interventricular septum thickness (IVS) was determined in 79 genetically independent subjects with HCM. Aldosterone in HCM hearts and plasma was similar to that in normal hearts and plasma. In HCM women, no associations between CYP11B2 genotype and any of the measured parameters were observed, whereas in HCM men, LVMI increased with the presence of the T allele. Similar T allele-related increases were observed for IVS. Multiple regression analysis revealed that the T allele-related effect on IVS occurred independently of renin, the ACE I/D polymorphism, the AT1-receptor A/C(1166)polymorphism and the AT2-receptor A/C(3123) polymorphism. In conclusion, circulating and cardiac aldosterone are normal in HCM, thereby arguing against selectively increased cardiac aldosterone production in HCM. Thus, the association between the CYP11B2 C-344T polymorphism and hypertrophy in HCM most likely relates to the T allele-related increases in circulating aldosterone. This finding raises the need for studies determining the benefit of aldosterone blockade in HCM.
Wenxia Chai; Yvonne Hoedemaekers; Ron H N van Schaik; Marianne van Fessem; Ingrid M Garrelds; Jasper J Saris; Dennis Dooijes; Folkert J ten Cate; Marcel M J Kofflard; A H Jan Danser
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the renin-angiotensin-aldosterone system : JRAAS     Volume:  7     ISSN:  1470-3203     ISO Abbreviation:  J Renin Angiotensin Aldosterone Syst     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-04-16     Revised Date:  2007-08-29    
Medline Journal Info:
Nlm Unique ID:  100971636     Medline TA:  J Renin Angiotensin Aldosterone Syst     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  IM    
Department of Pharmacology, Erasmus MC, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Aldosterone / metabolism*
Aldosterone Synthase / genetics*,  metabolism
Cardiomyopathy, Hypertrophic / genetics,  metabolism*
Middle Aged
Myocardium / metabolism*
Polymorphism, Single Nucleotide
Reg. No./Substance:
52-39-1/Aldosterone; EC Synthase

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