Document Detail

Cardiac adipose tissue: A new frontier for cardiac regeneration?
MedLine Citation:
PMID:  22709728     Owner:  NLM     Status:  Publisher    
The human heart has limited regenerative capacity. We focused on cardiac adipose tissue as a source of progenitor cells and biological matrix material for salvaging injured myocardium. First, a population of human adult mesenchymal-like progenitors derived from cardiac adipose tissue, with inherent cardiac and endothelial cell potential, was identified and characterized. Next, a salvage strategy was tested, where a pericardial-derived, vascularized, adipose flap was used to cover oxygen-deprived myocardium in a porcine model. The fat flap reduced the myocardial scar size, in both acute and chronic infarcts. A human clinical trial to examine this novel intervention is currently underway.
Antoni Bayes-Genis; Carolina Gálvez-Montón; Cristina Prat-Vidal; Carolina Soler-Botija
Related Documents :
23097168 - Dual-energy ct of the heart.
23092098 - Morphologic characterization and quantification of superficial calcifications of the co...
23121518 - Tlr4 expression on monocyte subsets in myocardial infarction.
13859058 - Selectivity in the study of the cardiovascular system.
24011548 - Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by car...
17281078 - Adaptive ventricular rate smoothing during atrial fibrillation: a pilot comparison study.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-16
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
ICREC (Heart Failure and Cardiac Regeneration) Research Program, Health Sciences Research Institute Germans Trias i Pujol (IGTP), Cardiology Service, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain; Department of Medicine, Autonomous University of Barcelona (UAB), Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  An evidence-based review of current anti-platelet options for STEMI patients.
Next Document:  Long-term use of angiotensin II receptor blockers and risk of cancer: A population-based cohort anal...