Document Detail

Cardiac adaptation in small for gestational age neonates after prenatal hemodynamic disturbances.
MedLine Citation:
PMID:  12782424     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Small for gestational age neonates with prenatal hemodynamic disturbances are at increased risk for neonatal morbidity. Investigations of fetal cardiac function have proved some functional impairments. The aim of the study was to investigate postnatal cardiac adaptation in these neonates in comparison with neonates without prenatal hemodynamic impairments. METHODS AND RESULTS: Forty-one neonates with prenatal hemodynamic disturbances and 40 neonates with undisturbed prenatal hemodynamics were observed during the first 5 days of life. Doppler sonographic measurements of left ventricular time intervals, stroke volume, cardiac output and the incidence of patent ductus arteriosus were obtained in all neonates of both groups. Heart rate and blood pressure were recorded simultaneously. RESULTS: A higher incidence of patent ductus arteriosus and a diminished stroke volume, but increased cardiac output, based on a significantly increased heart rate, were determined in SGA neonates with prenatal hemodynamic disturbances. In contrast, systolic left ventricular time intervals were not changed in these neonates, as expected. CONCLUSIONS: The described findings could be signs of persistent hemodynamic impairments in growth-retarded neonates with prenatal disturbed hemodynamics. The neonates revealed a reduced ability to compensate the prenatal hemodynamic disturbances. This aspect should be included in the discussion of perinatal management in cases of severe growth retardation.
Eva Robel-Tillig; Matthias Knüpfer; Christoph Vogtmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  72     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-03     Completed Date:  2003-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Department of Neonatology, University of Leipzig, Germany.
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MeSH Terms
Adaptation, Physiological / physiology*
Cardiac Output
Echocardiography, Doppler
Heart / embryology,  physiopathology*
Heart Defects, Congenital / physiopathology*
Infant, Newborn
Infant, Small for Gestational Age*
Prospective Studies
Ultrasonography, Prenatal
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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