Document Detail


Cardiac activity of isolated constituents of Inula racemosa.
MedLine Citation:
PMID:  17317650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Roots of the plant Inula racemosa are used as folk medicine in east Asia and Europe. Inula racemosa in combination with Commiphora mukul was reported to cure myocardial ischemia. However, systematic investigation of the plant for its specific role in heart diseases has not been conducted so far. In the present study, we have reported the isolation of four major constituents A, B, C and D along with some minor constituents from the plant Inula racemosa. Among the major constituent, constituent Dhas been selected first from spectral data and studied for its cardiac activity on isolated frog heart. The experimental data show that constituent D decreases heart rate and force of contraction at 40 mcg/ml. Actions of Adrenaline are blocked by constituent D and it also acts as an agonist for Propranolol. The studies indicate that constituent D produces a negative ionotropic and negative chronotropic effect on frog's heart. These studies can be utilized as a cardiac marker for exploring the cardiac activity of the plant Inula racemosa.
Authors:
P D Lokhande; B S Dhaware; S C Jagdale; A R Chabukswar; S A Mulkalwar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of herbal pharmacotherapy     Volume:  6     ISSN:  1522-8940     ISO Abbreviation:  J Herb Pharmacother     Publication Date:  2006  
Date Detail:
Created Date:  2007-02-23     Completed Date:  2007-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888586     Medline TA:  J Herb Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Affiliation:
The Center for Advanced Studies, Department of Organic Chemistry, University of Pune, India. pdlokhande@rediffmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Heart Rate / drug effects*
Inula*
Myocardial Contraction / drug effects*
Myocardial Ischemia / therapy
Phytotherapy*
Plant Extracts / pharmacology*
Plant Roots*
Ranidae
Stimulation, Chemical
Chemical
Reg. No./Substance:
0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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