Document Detail

Cardiac abnormalities in type 1 diabetes.
MedLine Citation:
PMID:  10933333     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Left ventricular (LV) structural and hemodynamic consequences of type 1 diabetes mellitus are not fully understood. METHODS: To evaluate LV geometry, systolic and diastolic function in type 1 diabetes, Doppler echocardiograms were performed in 40 normotensive, type 1 diabetic patients without coronary heart disease or valvular lesions (22 men, 18 women, mean age 43 +/- 6 years, body mass index 24.7 +/- 2.8 kg/m2) and in 40 age and sex-matched non-diabetic normotensive controls (22 men, 18 women, mean age 43 +/- 5 years, body mass index 23.2 +/- 2.8 kg/m2), in a case-control design. RESULTS: Patients had higher systolic blood pressure than controls (p < 0.03) and comparable diastolic blood pressure and heart rate. LV dimension and mass were higher in patients than in controls (both p < 0.0001) whereas relative wall thickness did not differ. For comparable levels of end-systolic stress, patients exhibited a higher ejection fraction than controls (p < 0.01) and normal midwall shortening. Cardiac output was also higher (p < 0.001), whereas total peripheral resistance was lower in patients than in controls (p < 0.0001). Isovolumic relaxation time and E deceleration were prolonged in patients and peak A velocity was greater than in controls (all p < 0.01), whereas the difference in duration between A and pulmonary vein peak reverse flow at atrial contraction was comparable. In subgroup analyses, all reported features were independent of a) presence of target organ damage; b) duration of disease; c) levels of glycosylated hemoglobin. CONCLUSIONS: In normotensive patients with type 1 diabetes: 1) there was a moderate increase in LV mass; 2) LV chamber function was supernormal and wall mechanics was normal; 3) LV active relaxation was impaired but chamber stiffness was normal.
G de Simone; G F Mureddu; O Vaccaro; R Greco; M Sacco; A Rivellese; F Contaldo; G Riccardi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian heart journal : official journal of the Italian Federation of Cardiology     Volume:  1     ISSN:  1129-471X     ISO Abbreviation:  Ital Heart J     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-11-20     Completed Date:  2000-11-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100909716     Medline TA:  Ital Heart J     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  493-9     Citation Subset:  IM    
Department of Clinical and Experimental Medicine, Federico II, University Hospital School of Medicine, Naples, Italy.
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MeSH Terms
Blood Pressure
Cardiac Output
Case-Control Studies
Diabetes Mellitus, Type 1 / complications*,  physiopathology
Echocardiography, Doppler
Heart Rate
Myocardial Contraction
Stroke Volume
Vascular Resistance
Ventricular Dysfunction, Left / complications*,  physiopathology,  ultrasonography

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