| Cardiac abnormalities in type 1 diabetes. | |
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MedLine Citation:
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PMID: 10933333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Left ventricular (LV) structural and hemodynamic consequences of type 1 diabetes mellitus are not fully understood. METHODS: To evaluate LV geometry, systolic and diastolic function in type 1 diabetes, Doppler echocardiograms were performed in 40 normotensive, type 1 diabetic patients without coronary heart disease or valvular lesions (22 men, 18 women, mean age 43 +/- 6 years, body mass index 24.7 +/- 2.8 kg/m2) and in 40 age and sex-matched non-diabetic normotensive controls (22 men, 18 women, mean age 43 +/- 5 years, body mass index 23.2 +/- 2.8 kg/m2), in a case-control design. RESULTS: Patients had higher systolic blood pressure than controls (p < 0.03) and comparable diastolic blood pressure and heart rate. LV dimension and mass were higher in patients than in controls (both p < 0.0001) whereas relative wall thickness did not differ. For comparable levels of end-systolic stress, patients exhibited a higher ejection fraction than controls (p < 0.01) and normal midwall shortening. Cardiac output was also higher (p < 0.001), whereas total peripheral resistance was lower in patients than in controls (p < 0.0001). Isovolumic relaxation time and E deceleration were prolonged in patients and peak A velocity was greater than in controls (all p < 0.01), whereas the difference in duration between A and pulmonary vein peak reverse flow at atrial contraction was comparable. In subgroup analyses, all reported features were independent of a) presence of target organ damage; b) duration of disease; c) levels of glycosylated hemoglobin. CONCLUSIONS: In normotensive patients with type 1 diabetes: 1) there was a moderate increase in LV mass; 2) LV chamber function was supernormal and wall mechanics was normal; 3) LV active relaxation was impaired but chamber stiffness was normal. |
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Authors:
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G de Simone; G F Mureddu; O Vaccaro; R Greco; M Sacco; A Rivellese; F Contaldo; G Riccardi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Italian heart journal : official journal of the Italian Federation of Cardiology Volume: 1 ISSN: 1129-471X ISO Abbreviation: Ital Heart J Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2000-11-20 Completed Date: 2000-11-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 100909716 Medline TA: Ital Heart J Country: ITALY |
Other Details:
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Languages: eng Pagination: 493-9 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine, Federico II, University Hospital School of Medicine, Naples, Italy. simogi@unina.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Cardiac Output Case-Control Studies Diabetes Mellitus, Type 1 / complications*, physiopathology Echocardiography, Doppler Female Heart Rate Humans Male Myocardial Contraction Stroke Volume Vascular Resistance Ventricular Dysfunction, Left / complications*, physiopathology, ultrasonography |
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