| Cardiac abnormalities associated with pheochromocytoma and other adrenal tumors. | |
| | |
MedLine Citation:
|
PMID: 19211391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To study the specific cardiac abnormalities associated with pheochromocytoma and to suggest a strategy for evaluating cardiac function in patients with pheochromocytoma. METHODS: In this case-control study, we reviewed pathology records of patients seen at Cedars-Sinai Medical Center between 1997 and 2007; patients with adrenal or extra-adrenal pheochromocytoma and those with nonfunctioning benign or malignant adrenal tumors were identified. Patients with functioning adrenal adenomas that secreted cortisol or aldosterone were excluded. Clinical history, imaging, pathology, biochemical test results, electrocardiographic findings, and echocardiographic findings were compared between patients with pheochromocytoma and patients with nonfunctioning adrenal tumors. RESULTS: The charts of 22 patients with pheochromocytoma and 35 patients with nonfunctioning adrenal tumors were included. No perioperative mortality was observed. The average age of patients with pheochromocytoma was similar to that of control patients (51.9 +/- 3.9 years vs 60.2 +/- 2.5 years, respectively), as was the number of patients with known cardiovascular diseases (2 [9%] in the pheochromocytoma group vs 5 [14%] in the control group). Two patients with pheochromocytoma (9%) exhibited myocardial damage. Abnormal electrocardiographic findings were present in 16 patients with pheochromocytoma (73%) and in 17 control patients (49%) (P = .1). QTc was prolonged in patients with pheochromocytoma compared with control patients (448.3 +/- 9.7 ms vs 424.7 +/- 4.5 ms, respectively; P = .02) and was correlated with levels of norepinephrine and normetanephrine, but not with levels of epinephrine and metanephrine or tumor size. ST-T abnormalities were present in 11 patients with pheochromocytoma (50%) and in 8 control patients (23%) (P = .04). Echocardiographic findings were normal in most patients with pheochromocytoma; abnormal left ventricular wall motion was documented in 3 patients with long QTc. CONCLUSIONS: The specific electrocardiographic findings in patients with pheochromocytoma are prolonged QTc and ST-T abnormalities. Performing an electrocardiogram in patients with pheochromocytoma would be prudent. Echocardiography would be useful to examine LV wall motion in patients with long QTc. Coronary artery disease should be excluded in patients with significant ST-T changes. |
| | |
Authors:
|
Run Yu; Lena Furmark; Christopher Wong |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 15 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2009 Jan-Feb |
Date Detail:
|
Created Date: 2009-02-12 Completed Date: 2009-05-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
|
Languages: eng Pagination: 10-6 Citation Subset: IM |
Affiliation:
|
Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. run.yu@cshs.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Gland Neoplasms
/
complications*,
physiopathology* Cardiovascular Diseases / etiology, physiopathology Case-Control Studies Echocardiography Electrocardiography Female Heart / physiopathology* Humans Male Middle Aged Norepinephrine / blood Normetanephrine / blood Pheochromocytoma / complications*, physiopathology* Retrospective Studies Ventricular Dysfunction, Left / etiology, physiopathology |
| Chemical | |
Reg. No./Substance:
|
51-41-2/Norepinephrine; 97-31-4/Normetanephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of thyroid Doppler in differential diagnosis of thyrotoxicosis.
Next Document: Beneficial effect of endocrinologist-performed ultrasonography on preoperative parathyroid adenoma l...