Document Detail

Cardiac Structure and Function in Cushing's Syndrome. A Cardiac Magnetic Resonance Imaging Study.
MedLine Citation:
PMID:  25093618     Owner:  NLM     Status:  Publisher    
Background: Patients with Cushing's syndrome have LV hypertrophy and dysfunction on echocardiography, but echo-based measurements may have limited accuracy in obese patients. No data are available on RV and LA size and function in these patients. Objectives: To evaluate left ventricular (LV), right ventricular (RV) and left atrial (LA) structure and function in patients with Cushing's syndrome by means of cardiac magnetic resonance (CMR), currently the reference modality in assessment of cardiac geometry and function. Methods: Eighteen patients with active Cushing's syndrome and 18 volunteers matched for age, sex and body mass index were studied by CMR. Imaging was repeated in the patients 6 (2-12) months after treatment of hypercortisolism. Results: Compared to controls, patients with Cushing's syndrome had lower LV, RV and LA ejection fractions (P<0.001 for all) and increased end-diastolic LV segmental thickness (P<0.001). Treatment of hypercortisolism was associated with an improvement in ventricular and atrial systolic performance, as reflected by a 15% increase in the LV ejection fraction (P=0.029), a 45% increase in the LA ejection fraction (P<0.001), and an 11% increase in the RV ejection fraction (NS). After treatment, the LV mass index and end-diastolic LV mass/volume ratio decreased by 17% (P<0.001) and 10% (P=0.002), respectively. None of the patients had late gadolinium myocardial enhancement. Conclusion: Cushing's syndrome is associated with subclinical biventricular and LA systolic dysfunction that are reversible after treatment. Despite skeletal muscle atrophy, Cushing's syndrome patients have an increased LV mass, reversible upon correction of hypercortisolism.
Peter Kamenický; Alban Redheuil; Charles Roux; Sylvie Salenave; Nadjia Kachenoura; Zainab Raissouni; Laurent Macron; Laurence Guignat; Christel Jublanc; Arshid Azarine; Sylvie Brailly; Jacques Young; Elie Mousseaux; Philippe Chanson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-5
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  jc20141783     Citation Subset:  -    
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