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Cardiac Structure and Function and Renal Insufficiency in the Oldest Old.
MedLine Citation:
PMID:  22911264     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: People over the age of 85 years have a high incidence of cardiovascular disease and chronic kidney disease. HYPOTHESIS: There is an association between renal function and cardiac structure and function in subjects 85 years of age. METHODS: Subjects born in the years 1920 and 1921 were recruited from the Jerusalem Longitudinal Cohort Study. Echocardiography was performed at the subject's home with assessment of cardiac structure and function. Glomerular filtration rate (GFR) was assessed by the Cockroft-Gault formula, with abnormal GFR defined as ≤60 mL/min/1.73 m(2) . RESULTS: There were 310 subjects who were enrolled. When GFR was examined as a continuous variable, linear regression showed a small although statistically significant relationship between GFR and left atrial volume (r = 0.15, P < 0.014), left ventricular mass index (r = 0.12, P < 0.04), and ejection fraction (r = 0.19, P < 0.03) but not with indices of diastolic function (r = 0.02, P < 0.72). However, using the accepted clinical cutoff of 60 mL/min/1.73 m(2) , there were no significant differences between subjects with normal and abnormal GFR in indices of cardiac structure. Ejection fraction (57.0 ± 10.4% vs 54.4 ± 10.3%; P = 0.08) and indices of diastolic function (E/e' 12.4 ± 5.0 vs 12.3 ± 4.6; P = 0.89) were not significantly different between the 2 groups. CONCLUSIONS: A weak and clinically insignificant association was found between GFR as a continuous variable and indices of cardiac function. However, using the clinically accepted cutoff, no association between abnormal GFR and cardiac structure or function was observed. David Leibowitz, MD, and Yoram Maaravi, MD, contributed equally to this report. The authors have no funding, financial relationships, or conflicts of interest to disclose.
Authors:
David Leibowitz; Yoram Maaravi; Irit Stessman-Lande; Jeremy M Jacobs; Dan Gilon; Jochanan Stessman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Clinical cardiology     Volume:  -     ISSN:  1932-8737     ISO Abbreviation:  Clin Cardiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
Affiliation:
Jerusalem Institute of Aging Research, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Heart Institute, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. oleibo@hadassah.org.il.
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