| Cardiac sarcoidosis and giant cell myocarditis as causes of atrioventricular block in young and middle-aged adults. | |
| | |
MedLine Citation:
|
PMID: 21427276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cardiac sarcoidosis (CS) and giant cell myocarditis (GCM) may present as high-degree atrioventricular block (AVB), but their proportion of the causal spectrum of AVB is not well-known. We investigated the prevalence of biopsy-verified CS and GCM in young and middle-aged adults undergoing pacemaker (PM) implantation for AVB. METHODS AND RESULTS: We used the PM registry of Helsinki University Central Hospital to identify all patients aged 18 to 55 years who underwent PM implantation for AVB between January 1999 and April 2009 and reviewed their medical records. In total, 133 patients had either second- or third-degree AVB as an indication for PM. Of them, 61 had a known cause for AVB, and they were excluded from further analyses. Among the remaining 72 patients with initially unexplained AVB, biopsy-verified CS or GCM was found in 14 (19%) and 4 (6%) patients, respectively. The majority (16/18, 89%) were women. Among the adult patients aged <55 years, the prevalence of CS and GCM combined was 14% (95% CI, 7.7% to 19.3%) of the whole AVB population and 25% (95% CI, 15% to 35%) of those with an initially unexplained AVB. Over an average of 48 months of follow-up, 7 (39%) of 18 patients with CS or GCM versus 1 of the 54 patients in whom AVB remained idiopathic, experienced either cardiac death, cardiac transplantation, ventricular fibrillation, or treated sustained ventricular tachycardia (P<0.001). CONCLUSIONS: CS and GCM explain ≥25% of initially unexplained AVB in young and middle-aged adults. These patients are at high risk for adverse cardiac events. |
| | |
Authors:
|
Riina Kandolin; Jukka Lehtonen; Markku Kupari |
Related Documents
:
|
9588266 - Ankylosing spondylitis in singapore: a study of 150 patients and a local update. 8941496 - Corticosteroid-induced bone loss. prevention and management. 21551026 - Extended follow-up of unruptured intracranial aneurysms detected by presymptomatic scre... 8796366 - Bone alkaline phosphatase measured with a new immunoradiometric assay in patients with ... 3917596 - The role of imaging in infertility management. 6091876 - Elevated serum creatine kinase bb levels in patients with small cell lung cancer. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-22 |
Journal Detail:
|
Title: Circulation. Arrhythmia and electrophysiology Volume: 4 ISSN: 1941-3084 ISO Abbreviation: Circ Arrhythm Electrophysiol Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-06-15 Completed Date: 2011-09-01 Revised Date: 2012-02-03 |
Medline Journal Info:
|
Nlm Unique ID: 101474365 Medline TA: Circ Arrhythm Electrophysiol Country: United States |
Other Details:
|
Languages: eng Pagination: 303-9 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Finland. riina.kandolin@hus.fi |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age Factors Atrioventricular Block / epidemiology, etiology*, physiopathology Biopsy Cardiomyopathies / complications*, diagnosis, epidemiology Diagnosis, Differential Female Finland / epidemiology Follow-Up Studies Giant Cells / pathology* Humans Incidence Magnetic Resonance Imaging, Cine / methods Male Middle Aged Myocarditis / complications*, diagnosis, epidemiology Myocardium / pathology* Positron-Emission Tomography Prognosis Retrospective Studies Risk Factors Sarcoidosis / complications*, diagnosis, epidemiology Young Adult |
| Comments/Corrections | |
Comment In:
|
Circ Arrhythm Electrophysiol. 2011 Jun;4(3):260-1
[PMID:
21673024
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coverage Policy for Neurorehabilitation: An International Perspective.
Next Document: Myosin XI-Dependent Formation of Tubular Structures from Endoplasmic Reticulum Isolated from Tobacco...