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Cardiac Rhythm Disturbances Associated with Amlodipine Acute Intoxication.
MedLine Citation:
PMID:  22740057     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Amlodipine is a dihydropyridine calcium channel antagonist extensively used for the treatment of arterial hypertension, with predominant effect on the peripheral vascular territory. In most cases of severe intoxication, important hypotension and reflex tachycardia are usually observed. We report a case of young man with severe amlodipine intoxication that developed important bradyarrhythmias, such as low atrial rhythm, prolonged PR interval, atrioventricular block, and left bundle branch block. These rhythm disturbances suggest that, during acute intoxication, dihydropyridine loses its selective action on the vascular territory and can depress automatism and conduction of cardiac electrical stimulus.
Authors:
Carlos Henrique Miranda; Leudo Xavier; Flávio Fiorante; Gustavo Prata Misiara; Ellen Gonçalves Guimarães; Ana Marta Galli; Antônio Pazin-Filho; Marcos de Carvalho Borges
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Cardiovascular toxicology     Volume:  -     ISSN:  1559-0259     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135818     Medline TA:  Cardiovasc Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Emergency Medicine, Department of Internal Medicine, São Paulo University Medical School at Ribeirão Preto, Rua Bernardino de Campos, 1000, Ribeirão Preto, SP, 14015-130, Brazil, chmirand@yahoo.com.br.
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