| Cardiac resynchronization therapy: refocus on the electrical substrate. | |
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MedLine Citation:
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PMID: 21532178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac resynchronization therapy (CRT) is an established treatment for selected heart failure patients with conduction disease. Many studies aimed at quantifying mechanical dyssynchrony in CRT candidates when it became apparent that 30-50% of CRT recipients showed no improvement after implantation. As these, often echocardiography-based, measurements have not yet succeeded in estimating the mechanical substrate in an accurate and reproducible manner, interest in electrical substrate has renewed. In this review, current knowledge concerning electrical substrate in CRT candidates will be explored and applied to current CRT practice, highlighting why the electrical substrate is both essential and sufficient for successful CRT. Finally, novel ways to better measure and treat the electrical substrate are discussed. |
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Authors:
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Marc Strik; Sylvain Ploux; Kevin Vernooy; Frits W Prinzen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-04-29 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 75 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-26 Completed Date: 2011-09-16 Revised Date: 2012-01-09 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1297-304 Citation Subset: IM |
Affiliation:
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Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Bundle-Branch Block / physiopathology, therapy* Cardiac Resynchronization Therapy* Heart Conduction System / physiopathology* Heart Failure / physiopathology, therapy* Humans Kinetics Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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