Document Detail

Cardiac protection during on-pump coronary artery bypass grafting: ischemic versus isoflurane preconditioning.
MedLine Citation:
PMID:  20656748     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the cardioprotective effects of anesthetic preconditioning by isoflurane with ischemic preconditioning.
METHODS: A total of 45 patients scheduled for elective coronary artery bypass graft (CABG) surgery were randomized to preconditioning either by 3 episodes of 1-minute aortic cross-clamping followed by 4 minutes of reperfusion after each episode, a 10-minute exposure to isoflurane 2.5% followed by 5 minutes of washout, or no preconditioning technique (control group). Hemodynamic data, cardiac troponin I (cTnI), creatine kinase isoenzyme MB (CK-MB) release, need for inotropic support, hospital stay, and adverse cardiac events were measured and recorded.
RESULTS: Preconditioned patients showed marked improvement in hemodynamic data, less need for inotropic support, and less postoperative increase in the serum levels of CK-MB and cTnI. No significant difference in hospital stay was found. Also, 4 patients in the control group had adverse cardiac events versus 1 patient in the isoflurane and ischemic groups in 1 year of follow-up.
CONCLUSIONS: Based on this very small sample size, these data support a cardioprotective effect of isoflurane and ischemic preconditioning during CABG surgery.
Yasser Mohamed Amr; Ibrahim M Yassin
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-07-23
Journal Detail:
Title:  Seminars in cardiothoracic and vascular anesthesia     Volume:  14     ISSN:  1940-5596     ISO Abbreviation:  Semin Cardiothorac Vasc Anesth     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-13     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9807630     Medline TA:  Semin Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Tanta University, Egypt.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Coronary Artery Bypass / adverse effects,  methods*
Creatine Kinase, MB Form / blood
Follow-Up Studies
Ischemic Preconditioning, Myocardial / methods*
Isoflurane / pharmacology*
Length of Stay
Middle Aged
Troponin I / blood
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Troponin I; 26675-46-7/Isoflurane; EC Kinase, MB Form

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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