Document Detail

The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype.
MedLine Citation:
PMID:  20505520     Owner:  NLM     Status:  MEDLINE    
Disorders of the cardiac conduction system occur frequently and may cause life-threatening arrhythmias requiring medication or electronic pacemaker implantation. Repair or regeneration of conduction system components is currently not possible due to limited knowledge of the molecular regulation of pacemaker myocardium. Origin and development of the cardiac conduction system have been subject to debate for many decades. This review will discuss recent advances in our understanding of the molecular regulation of the development of the conduction system. We conclude that the components of the cardiac conduction system originate from embryonic myocardium that has maintained essential features of its primitive phenotype, whereas the adjacent myocardium differentiates into working myocardium.
Martijn L Bakker; Vincent M Christoffels; Antoon F M Moorman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  56     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6-15     Citation Subset:  IM    
Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology
Gene Expression Regulation
Heart Conduction System / embryology,  physiology*,  physiopathology
Myocardium / metabolism*
Myocytes, Cardiac / metabolism

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